Copa Sudamericana
FIFA Region
CONMEBOL
Season
2022
Location
South America
Abbreviation
COPASUD
Summary
The 2022 Copa Sudamericana is South America's second most prestigous club football tournament where top club teams (44 total) from all 10 CONMEBOL F/As (football associations) are represented. It is the equivalent of the UEFA Europa League. The 2022 winner will play in the 2023 Copa Libertadores.
Each F/A is given a minimum of 4 berths, while Argentina and Brazil are each given 6. Stage entry is based on cummulative historical relative performance of each F/A against the other F/As.
Atlético Paranaense (BRA1) won the 2021 Copa Sudamericana.
More Info...
2022 Copa Sudamericana Berths
| F/A | COPALIB Teams | COPASUD Teams |
|---|---|---|
| Argentina | 6 | 6 |
| Boliva | 4 | 4 |
| Brazil | 9 | 6 |
| Chile | 4 | 4 |
| Colombia | 4 | 4 |
| Ecuador | 4 | 4 |
| Paraguay | 4 | 4 |
| Peru | 4 | 4 |
| Uruguay | 4 | 4 |
| Venezuela | 4 | 4 |
Competition Structure
| Stage | # Teams | New Teams Entering This Round | Teams From Previous Round | Format |
|---|---|---|---|---|
| First Stage | 32 |
| 16 sets of Home/Away matches, highest aggregate goals advances | |
| Group Stage | 32 |
| 16 winners from First Round | 8 groups of 4 with Home/Away matches against each team in group, top team with most points (win = 3 pts, draw = 1 pt) in each group advance |
| Round of 16 | 16 | eight 3rd place teams from 2022 Copa Libertadores Group Stage | 8 winners from Group Stage | 8 sets of Home/Away matches, highest aggregate goals advances |
| Quarterfinals | 8 | None | 8 winners from Round of 16 | 4 sets of Home/Away matches, highest aggregate goals advances |
| Semifinals | 4 | None | 4 winners from Quarterfinals | 2 sets of Home/Away matches, highest aggregate goals advances |
| Final | 2 | None | 2 winners from Semifinals | Home/Away matches, highest aggregate goals wins |
Final
| Date | Home | Status | Road | Venue | ||||
Sat - 1 Oct 2022
 | 02 | CSD Independiente (ECU1) | Estadio Mario Alberto Kempes |
Semifinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | CSD Independiente (ECU1) | 60 | FBC Melgar (PER1) |
| 31.08.22 | | 30 | FBC Melgar | Estadio Rodrigo Paz Delgado |
| 07.09.22 | | 03 | CSD Independiente | Estadio Monumental Virgen de Chapi de La UNSA |
| Aggregate | Atletico GO (BRA1) | 33 | São Paulo (BRA1) |
| 01.09.22 |  | 31 | São Paulo | Estádio Serra Dourada |
| 08.09.22 | | 20 | Atletico GO | Estádio do Morumbi | ||
| São Paulo advances on PKs (4-2) | ||||||
Quarterfinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Nacional (URU1) | 04 | Atletico GO (BRA1) |
| 02.08.22 |  | 01 | Atletico GO | Estadio Gran Parque Central |
| 09.08.22 | | 30 | Nacional | Estádio Serra Dourada |
| Aggregate | Deportivo Tachira (VEN1) | 15 | CSD Independiente (ECU1) |
| 02.08.22 |  | 01 | CSD Independiente | Estadio Polideportivo de Pueblo Nuevo |
| 09.08.22 | | 41 | Deportivo Tachira | Estadio Rodrigo Paz Delgado |
| Aggregate | Sao Paulo (BRA1) | 53 | Ceara (BRA1) |
| Aggregate | FBC Melgar (PER1) | 31 | Internacional (BRA1) |
| 04.08.22 | | 00 | Internacional | Estadio Monumental Virgen de Chapi de La UNSA |
| 11.08.22 | | 13 | FBC Melger | Estádio Beira-Rio |
Round of 16
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Nacional (URU1) | 41 | Unión de Santa Fe (ARG1) |
| 28.06.22 | | 20 | Unión de Santa Fe | Estadio Gran Parque Central |
| Aggregate | CSD Colo-Colo (CHI1) | 34 | Internacional (BRA1) |
| 28.06.22 |  | 20 | Internacional | Estadio Monumental David Arrellano |
| 05.07.22 | | 41 | Colo Colo | Estádio Beira-Rio |
| Aggregate | Club The Strongest (BOL1) | 15 | Ceará (BRA1) |
| 29.06.22 |  | 12 | Ceará | Estadio Hernando Siles |
| 06.07.22 | | 30 | The Strongest | Castelão (Ceará) |
| Aggregate | Deportivo Táchira FC (VEN1) | 53 | Santos FC (BRA1) |
| 29.06.22 | | 11 | Santos FC | Estadio Polideportivo de Pueblo Nuevo |
| 06.07.22 | | 24 | Deportivo Tachira | Estádio Urbano Caldeira |
| Aggregate | AC Deportivo Cali (COL1) | 12 | FBC Melgar (PER1) |
| 29.06.22 |  | 00 | FBC Melgar | Estadio Deportivo Cali |
| 06.07.22 | | 21 | AC Deportivo Cali | Estadio Monumental Virgen de Chapi de La UNSA |
| Aggregate | CSD Independiente (ECU1) | 21 | Lanús (ARG1) |
| 30.06.22 | | 21 | Lanús | Estadio Olímpico Atahualpa |
| 07.07.22 | | 00 | CSD Independiente | Estadio Ciudad de Lanús - Néstor Díz Pérez |
| Aggregate | CD Univ Católica (CHI1) | 38 | São Paulo (BRA1) |
| 30.06.22 |  | 24 | São Paulo | Estadio San Carlos de Apoquindo |
| 07.07.22 | | 41 | Universidad Catolica | Estádio do Morumbi |
| Aggregate | Club Olimpia (PAR1) | 55 | Goianiense (BRA1) |
| 30.06.22 |  | 20 | Goianiense | Estadio Defensores del Chaco (Asunción) |
| 07.07.22 | | 53 | Olimpia | Estádio Serra Dourada |
Group Stage
| Group A | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Lanús (ARG1) | 6 | 3 -2-1 | 11 | - | 7 | 4 | 3 | 3 | 2 -0-1 | 6 | 5 | 3 | 2 | 3 | 1 -2-0 | 5 | 2 | 1 | 1 |
| 2 | Barcelona SC (ECU1) | 6 | 2 -3-1 | 9 | - | 9 | 8 | 1 | 3 | 2 -1-0 | 7 | 6 | 3 | 3 | 3 | 0 -2-1 | 2 | 3 | 5 | -2 |
| 3 | Wanderers FC (URU1) | 6 | 2 -2-2 | 8 | - | 6 | 7 | -1 | 3 | 0 -2-1 | 2 | 1 | 2 | -1 | 3 | 2 -0-1 | 6 | 5 | 5 | 0 |
| 4 | Metropolitanos FC (VEN1) | 6 | 0 -3-3 | 3 | - | 3 | 6 | -3 | 3 | 0 -2-1 | 2 | 2 | 3 | -1 | 3 | 0 -1-2 | 1 | 1 | 3 | -2 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 07.04.22 |  | 42 | Wanderers FC | Estadio Banco Pichincha |
 | 00 | Lanús | Estadio Olímpico de la UCV |
| 14.04.22 | | 11 | Metropolitanos FC | Estadio Centenario (Montevideo) |
| 31 | Barcelona SC | Estadio Ciudad de Lanús |
| 28.04.22 | | 01 | Lanús | Estadio Centenario (Montevideo) |
| 10 | Metropolitanos FC | Estadio Banco Pichincha |
| 04.05.22 | | 01 | Wanderers FC | Estadio Olímpico de la UCV |
| 11 | Lanús | Estadio Banco Pichincha |
| 19.05.22 | | 12 | Wanderers FC | Estadio Ciudad de Lanús |
| 22 | Barcelona SC | Estadio Olímpico de la UCV |
| 25.05.22 | | 10 | Metropolitanos FC | Estadio Ciudad de Lanús |
| 00 | Barcelona SC | Estadio Centenario (Montevideo) |
| Group B | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | FBC Melgar (PER1) | 6 | 4 -0-2 | 12 | - | 10 | 6 | 4 | 3 | 3 -0-0 | 9 | 8 | 2 | 6 | 3 | 1 -0-2 | 3 | 2 | 4 | -2 |
| 2 | Racing Club (ARG1) | 6 | 4 -0-2 | 12 | - | 7 | 5 | 2 | 3 | 2 -0-1 | 6 | 3 | 1 | 2 | 3 | 2 -0-1 | 6 | 4 | 4 | 0 |
| 3 | Cuiabá EC (BRA2) | 6 | 2 -0-4 | 6 | - | 7 | 10 | -3 | 3 | 1 -0-2 | 3 | 4 | 4 | 0 | 3 | 1 -0-2 | 3 | 3 | 6 | -3 |
| 4 | CA River Plate (URU1) | 6 | 2 -0-4 | 6 | - | 5 | 8 | -3 | 3 | 0 -0-3 | 0 | 2 | 5 | -3 | 3 | 2 -0-1 | 6 | 3 | 3 | 0 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 07.04.22 |  | 20 | FBC Melgar | Arena Pantanal |
 | 01 | Racing Club | Estadio Centenario (Montevideo) |
| 13.04.22 | | 20 | CA River Plate | Estadio Monumental Virgen de Chapi de La UNSA |
| 20 | Cuiabá EC | El Cilindro |
| 27.04.22 | | 31 | Racing Club | Estadio Monumental Virgen de Chapi de La UNSA |
| 12 | CA River Plate | Arena Pantanal |
| 03.05.22 | | 12 | FBC Melgar | Estadio Centenario (Montevideo) |
| 12 | Racing Club | Arena Pantanal |
| 18.05.22 | | 12 | Cuiabá EC | Estadio Centenario (Montevideo) |
| 10 | FBC Melgar | El Cilindro |
| 26.05.22 | | 01 | CA River Plate | El Cilindro |
| 31 | Cuiabá EC | Estadio Monumental Virgen de Chapi de La UNSA |
| Group C | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Santos FC (BRA1) | 6 | 3 -2-1 | 11 | - | 7 | 5 | 2 | 3 | 2 -1-0 | 7 | 5 | 3 | 2 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 |
| 2 | CD Unión La Calera (CHI1) | 6 | 3 -2-1 | 11 | - | 6 | 4 | 2 | 3 | 2 -1-0 | 7 | 5 | 3 | 2 | 3 | 1 -1-1 | 4 | 1 | 1 | 0 |
| 3 | CD Univ Católica (ECU1) | 6 | 1 -2-3 | 5 | - | 7 | 8 | -1 | 3 | 1 -1-1 | 4 | 2 | 1 | 1 | 3 | 0 -1-2 | 1 | 5 | 7 | -2 |
| 4 | Banfield (ARG1) | 6 | 1 -2-3 | 5 | - | 3 | 6 | -3 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 | 3 | 0 -1-2 | 1 | 1 | 4 | -3 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 05.04.22 |  | 00 | CD Unión La Calera | Estadio Olímpico Atahualpa |
| 13.04.22 | | 32 | CD Univ Católica | Estádio Urbano Caldeira |
| 14.04.22 | | 10 | Banfield | Estadio Sausalito |
| 27.04.22 | | 20 | Banfield | Estadio Olímpico Atahualpa |
| 28.04.22 | | 11 | Santos FC | Estadio Sausalito |
| 05.05.22 | | 01 | CD Unión La Calera | Estadio Florencio Sola |
| 01 | Santos FC | Estadio Olímpico Atahualpa |
| 17.05.22 | | 11 | CD Univ Católica | Estadio Florencio Sola |
| 18.05.22 | | 10 | CD Unión La Calera | Estádio Urbano Caldeira |
| 32 | CD Univ Católica | Estadio Sausalito |
| Group D | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | São Paulo (BRA1) | 6 | 5 -1-0 | 16 | - | 12 | 3 | 9 | 3 | 3 -0-0 | 9 | 6 | 0 | 6 | 3 | 2 -1-0 | 7 | 6 | 3 | 3 |
| 2 | CD Everton (CHI1) | 6 | 3 -2-1 | 11 | - | 7 | 4 | 3 | 3 | 1 -2-0 | 5 | 3 | 2 | 1 | 3 | 2 -0-1 | 6 | 4 | 2 | 2 |
| 3 | Ayacucho FC (PER1) | 6 | 1 -1-4 | 4 | - | 5 | 8 | -3 | 3 | 0 -1-2 | 1 | 2 | 5 | -3 | 3 | 1 -0-2 | 3 | 3 | 3 | 0 |
| 4 | Club Jorge Wilstermann (BOL1) | 6 | 0 -2-4 | 2 | - | 2 | 11 | -9 | 3 | 0 -0-3 | 0 | 1 | 7 | -6 | 3 | 0 -2-1 | 2 | 1 | 4 | -3 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 05.04.22 |  | 11 | Club Jorge Wilstermann | Estadio Sausalito |
| 07.04.22 |  | 23 | São Paulo | Estadio Nacional de Lima |
| 13.04.22 | | 02 | Ayacucho FC | Estadio Félix Capriles |
| 14.04.22 | | 20 | CD Everton | Estádio do Morumbi |
| 26.04.22 | | 21 | Ayacucho FC | Estadio Sausalito |
| 28.04.22 | | 13 | São Paulo | Estadio Félix Capriles |
| 05.05.22 | | 00 | São Paulo | Estadio Sausalito |
| 00 | Club Jorge Wilstermann | Estadio Garcilaso |
| 18.05.22 | | 02 | CD Everton | Estadio Garcilaso |
| 19.05.22 | | 30 | Club Jorge Wilstermann | Estádio do Morumbi |
| 25.05.22 | | 10 | Ayacucho FC | Estádio do Morumbi |
| 02 | CD Everton | Estadio Félix Capriles |
| Group E | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Internacional (BRA1) | 6 | 3 -3-0 | 12 | - | 12 | 5 | 7 | 3 | 2 -1-0 | 7 | 8 | 2 | 6 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 |
| 2 | Guaireña FC (PAR2) | 6 | 2 -4-0 | 10 | - | 10 | 8 | 2 | 3 | 1 -2-0 | 5 | 5 | 4 | 1 | 3 | 1 -2-0 | 5 | 5 | 4 | 1 |
| 3 | Independiente Medellín (COL1) | 6 | 1 -2-3 | 5 | - | 8 | 11 | -3 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 | 3 | 0 -1-2 | 1 | 5 | 8 | -3 |
| 4 | Club 9 de Octubre (ECU2) | 6 | 1 -1-4 | 4 | - | 9 | 15 | -6 | 3 | 1 -1-1 | 4 | 7 | 7 | 0 | 3 | 0 -0-3 | 0 | 2 | 8 | -6 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 06.04.22 |  | 22 | Internacional | Estadio Jocay |
| 07.04.22 |  | 33 | Independiente Medellín | Estadio Defensores del Chaco (Asunción) |
| 14.04.22 | | 21 | Club 9 de Octubre | Estadio Hernán Ramírez Villegas |
| 11 | Guaireña FC | Estádio Beira-Rio |
| 26.04.22 | | 01 | Internacional | Estadio Hernán Ramírez Villegas |
| 27.04.22 | | 10 | Club 9 de Octubre | Estadio Defensores del Chaco (Asunción) |
| 03.05.22 | | 32 | Independiente Medellín | Estadio Jocay |
| 05.05.22 | | 11 | Internacional | Estadio Defensores del Chaco (Asunción) |
| 17.05.22 | | 20 | Independiente Medellín | Estádio Beira-Rio |
| 23 | Guaireña FC | Estadio Jocay |
| 24.05.22 | | 51 | Club 9 de Octubre | Estádio Beira-Rio |
| 11 | Guaireña FC | Estadio Hernán Ramírez Villegas |
| Group F | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Goianiense (BRA2) | 6 | 4 -1-1 | 13 | - | 11 | 5 | 6 | 3 | 3 -0-0 | 9 | 8 | 2 | 6 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 |
| 2 | LDU Quito (ECU1) | 6 | 3 -2-1 | 11 | - | 11 | 9 | 2 | 3 | 1 -2-0 | 5 | 7 | 3 | 4 | 3 | 2 -0-1 | 6 | 4 | 6 | -2 |
| 3 | Deportes Antofagasta (CHI2) | 6 | 2 -0-4 | 6 | - | 6 | 11 | -5 | 3 | 1 -0-2 | 3 | 4 | 6 | -2 | 3 | 1 -0-2 | 3 | 2 | 5 | -3 |
| 4 | Defensa y Justicia (ARG1) | 6 | 1 -1-4 | 4 | - | 8 | 11 | -3 | 3 | 0 -0-3 | 0 | 1 | 5 | -4 | 3 | 1 -1-1 | 4 | 7 | 6 | 1 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 05.04.22 | | 40 | LDU Quito | Estádio Antônio Accioly |
| 06.04.22 |  | 13 | Defensa y Justicia | Estadio Regional de Antofagasta |
| 12.04.22 | | 01 | Goianiense | Estadio Norberto Tomaghello |
| 40 | Deportes Antofagasta | Estadio Rodrigo Paz Delgado |
| 27.04.22 | | 21 | Goianiense | Estadio Regional de Antofagasta |
| 28.04.22 | | 12 | LDU Quito | Estadio Norberto Tomaghello |
| 04.05.22 | | 32 | Defensa y Justicia | Estádio Antônio Accioly |
| 12 | LDU Quito | Estadio Regional de Antofagasta |
| 17.05.22 | | 10 | Deportes Antofagasta | Estádio Antônio Accioly |
| 18.05.22 | | 22 | Defensa y Justicia | Estadio Rodrigo Paz Delgado |
| 24.05.22 | | 11 | Goianiense | Estadio Rodrigo Paz Delgado |
| 02 | Deportes Antofagasta | Estadio Norberto Tomaghello |
| Group G | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Ceará (BRA1) | 6 | 6 -0-0 | 18 | - | 17 | 1 | 16 | 3 | 3 -0-0 | 9 | 11 | 1 | 10 | 3 | 3 -0-0 | 9 | 6 | 0 | 6 |
| 2 | Independiente (ARG1) | 6 | 4 -0-2 | 12 | - | 13 | 4 | 9 | 3 | 2 -0-1 | 6 | 6 | 2 | 4 | 3 | 2 -0-1 | 6 | 7 | 2 | 5 |
| 3 | General Caballero JLM (PAR1) | 6 | 1 -1-4 | 4 | - | 2 | 15 | -13 | 3 | 0 -1-2 | 1 | 1 | 7 | -6 | 3 | 1 -0-2 | 3 | 1 | 8 | -7 |
| 4 | Deportivo La Guaira (VEN1) | 6 | 0 -1-5 | 1 | - | 1 | 13 | -12 | 3 | 0 -0-3 | 0 | 0 | 5 | -5 | 3 | 0 -1-2 | 1 | 1 | 8 | -7 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 05.04.22 | | 21 | Independiente | Castelão (Ceará) |
| 06.04.22 |  | 11 | Deportivo La Guaira | Estadio Defensores del Chaco (Asunción) |
| 12.04.22 | | 02 | Ceará | Estadio Olímpico de la UCV |
| 20 | General Caballero JLM | Estadio Libertadores de América |
| 26.04.22 | | 02 | Independiente | Estadio Olímpico de la UCV |
| 02 | Ceará | Estadio Manuel Ferreira |
| 03.05.22 | | 30 | Deportivo La Guaira | Castelão (Ceará) |
| 04 | Independiente | Estadio Defensores del Chaco (Asunción) |
| 17.05.22 | | 60 | General Caballero JLM | Castelão (Ceará) |
| 19.05.22 | | 40 | Deportivo La Guaira | Estadio Libertadores de América |
| 25.05.22 | | 02 | Ceará | Estadio Libertadores de América |
| 01 | General Caballero JLM | Estadio Olímpico de la UCV |
| Group H | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Unión de Santa Fe (ARG1) | 6 | 3 -3-0 | 12 | - | 10 | 2 | 8 | 3 | 1 -2-0 | 5 | 3 | 1 | 2 | 3 | 2 -1-0 | 7 | 7 | 1 | 6 |
| 2 | Fluminense FC (BRA1) | 6 | 3 -2-1 | 11 | - | 15 | 5 | 10 | 3 | 2 -1-0 | 7 | 5 | 1 | 4 | 3 | 1 -1-1 | 4 | 10 | 4 | 6 |
| 3 | Junior de Barranquilla (COL1) | 6 | 3 -1-2 | 10 | - | 10 | 8 | 2 | 3 | 2 -0-1 | 6 | 5 | 4 | 1 | 3 | 1 -1-1 | 4 | 5 | 4 | 1 |
| 4 | Oriente Petrolero (BOL1) | 6 | 0 -0-6 | 0 | - | 3 | 23 | -20 | 3 | 0 -0-3 | 0 | 3 | 16 | -13 | 3 | 0 -0-3 | 0 | 0 | 7 | -7 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 06.04.22 |  | 30 | Oriente Petrolero | Estádio do Maracanã |
| 11 | Junior de Barranquilla | Estadio 15 de Abril |
| 12.04.22 | | 13 | Unión de Santa Fe | Estadio Ramón Tahuichi Aguilera |
| 13.04.22 | | 30 | Fluminense FC | Estadio Metropolitano Roberto Meléndez |
| 26.04.22 | | 00 | Unión de Santa Fe | Estádio do Maracanã |
| 28.04.22 | | 13 | Junior de Barranquilla | Estadio Ramón Tahuichi Aguilera |
| 04.05.22 | | 21 | Junior de Barranquilla | Estádio do Maracanã |
| 05.05.22 | | 20 | Oriente Petrolero | Estadio 15 de Abril |
| 17.05.22 | | 20 | Oriente Petrolero | Estadio Metropolitano Roberto Meléndez |
| 19.05.22 | | 00 | Fluminense FC | Estadio 15 de Abril |
| 26.05.22 | | 04 | Unión de Santa Fe | Estadio Metropolitano Roberto Meléndez |
| 110 | Fluminense FC | Estadio Ramón Tahuichi Aguilera |
First Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Royal Pari FC (BOL1) | 26 | Oriente Petrolero (BOL1) |
| 08.03.22 |  | 23 | Oriente Petrolero | Estadio Ramón Tahuichi Aguilera |
| 15.03.22 | | 30 | Royal Pari FC | Estadio Ramón Tahuichi Aguilera |
| Aggregate | Estudiantes de Mérida (VEN1) | 06 | Metropolitanos FC (VEN1) |
| 08.03.22 |  | 02 | Metropolitanos FC | Estadio Metropolitano de Mérida |
| 15.03.22 | | 40 | Estudiantes de Mérida | Estadio Olímpico de la UCV |
| Aggregate | Club Sol de América (PAR1) | 15 | General Caballero JLM (PAR1) |
| 08.03.22 |  | 03 | General Caballero JLM | Estadio Defensores del Chaco (Asunción) |
| 15.03.22 | | 21 | Club Sol de América | Estadio Defensores del Chaco (Asunción) |
| Aggregate | Ñublense (CHI1) | 12 | CD Unión La Calera (CHI1) |
| 08.03.22 |  | 00 | CD Unión La Calera | Estadio Municipal Nelson Oyarzún Arenas |
| 15.03.22 | | 21 | Ñublense | Estadio Sausalito |
| Aggregate | Club Cienciano (PER1) | 12 | FBC Melgar (PER1) |
| 08.03.22 |  | 11 | FBC Melgar | Estadio Garcilaso |
| 15.03.22 | | 10 | Club Cienciano | Estadio Monumental Virgen de Chapi de La UNSA |
| Aggregate | Liverpool FC (URU1) | 03 | CA River Plate (URU1) |
| 09.03.22 |  | 01 | CA River Plate | Estadio Centenario (Montevideo) |
| 16.03.22 | | 20 | Liverpool FC | Estadio Centenario (Montevideo) |
| Aggregate | Independiente Medellín (COL1) | 33 | América de Cali (COL1) |
| 09.03.22 | | 21 | América de Cali | Estadio Atanasio Giradot |
| 16.03.22 | | 21 | Independiente Medellín | Estadio Olímpico Pascual Guerrero |
| Aggregate | Mushuc Runa SC (ECU1) | 13 | LDU Quito (ECU1) |
| 09.03.22 |  | 02 | LDU Quito | Estadio Bellavista |
| 16.03.22 | | 11 | Mushuc Runa SC | Estadio Rodrigo Paz Delgado |
| Aggregate | Ayacucho FC (PER1) | 43 | Sport Boys (PER1) |
| 09.03.22 | | 20 | Sport Boys | Estadio Huancayo |
| 16.03.22 | | 32 | Ayacucho FC | Estadio Nacional de Lima |
| Aggregate | Club Unión Española (CHI1) | 22 | Deportes Antofagasta (CHI1) |
| 10.03.22 |  | 12 | Deportes Antofagasta | Estadio Santa Laura |
| 17.03.22 | | 01 | Club Unión Española | Estadio Regional de Antofagasta |
| Aggregate | Club Nacional (PAR1) | 01 | Guaireña FC (PAR1) |
| 10.03.22 |  | 01 | Guaireña FC | Estadio Defensores del Chaco (Asunción) |
| 17.03.22 | | 00 | Club Nacional | Estadio Defensores del Chaco (Asunción) |
| Aggregate | Hermanos Colmenares (VEN1) | 23 | Deportivo La Guaira (VEN1) |
| 10.03.22 |  | 20 | Deportivo La Guaira | Estadio Rafael Agustín Tovar |
| 17.03.22 | | 30 | Hermanos Colmenares | Estadio Olímpico de la UCV |
| Aggregate | Club Jorge Wilstermann (BOL1) | 43 | CD Guabirá (BOL1) |
| 10.03.22 | | 40 | CD Guabirá | Estadio Félix Capriles |
| 17.03.22 | | 30 | Club Jorge Wilstermann | Estadio Gilberto Parada |
| Aggregate | CD La Equidad (COL1) | 13 | Junior de Barranquilla (COL1) |
| 10.03.22 |  | 00 | Junior de Barranquilla | Estadio El Campín |
| 17.03.22 | | 31 | CD La Equidad | Estadio Metropolitano Roberto Meléndez |
| Aggregate | Delfín SC (ECU1) | 13 | Club 9 de Octubre (ECU1) |
| 10.03.22 |  | 11 | Club 9 de Octubre | Estadio Jocay |
| 17.03.22 | | 20 | Delfín SC | Estadio Christian Benítez Betancourt |
| Aggregate | Wanderers FC (URU1) | 31 | Cerro Largo FC (URU1) |
| 10.03.22 | | 21 | Cerro Largo FC | Estadio Parque Alfredo Victor Viera |
| 17.03.22 | | 01 | Wanderers FC | Estadio Centenario (Montevideo) |