UEFA Europa Conference League
FIFA Region
UEFA
Season
2021-2022
Location
Europe
Abbreviation
UEFAECL
Summary
The 2021-2022 UEFA Europa Conference League (UEFAECL) is Europe's 3rd tier of European club football competition (after UEFA Champions League (UEFACL) and UEFA Europa League (UEFAEL)) where 184 premier league/1st division club teams from all 55 UEFA F/As (football associations) are represented. This tournament is designed to be contested primarily by lower ranked football associations. UEFAECL's inaugural season will start in the Summer of 2021.
Club teams qualified for the 2021-2022 UEFAECL based on the 2020 UEFA F/A Rankings table. This table takes into account how teams from each F/A performed in European competitions from the 2015-2016 through the 2019-2020 seasons.
More Info...
2019 UEFA F/A Rankings
| F/A | UEFA Rank | CL Teams | EL Teams | ECL Teams |
|---|
| Spain | 1 | 4 | 2 | 1 |
| England | 2 | 4 | 2 | 1 |
| Italy | 3 | 4 | 2 | 1 |
| Germany | 4 | 4 | 2 | 1 |
| France | 5 | 3 | 2 | 1 |
| Portugal | 6 | 3 | 1 | 2 |
| Netherlands | 7 | 2 | 1 | 2 |
| Russia | 8 | 2 | 1 | 2 |
| Belgium | 9 | 2 | 1 | 2 |
| Austria | 10 | 2 | 1 | 2 |
| Scotland | 11 | 2 | 1 | 2 |
| Ukraine | 12 | 2 | 1 | 2 |
| Turkey | 13 | 2 | 1 | 2 |
| Denmark | 14 | 2 | 1 | 2 |
| Cyprus | 15 | 2 | 1 | 2 |
| Serbia | 16 | 1 | 0 | 3 |
| Czech Republic | 17 | 1 | 0 | 3 |
| Croatia | 18 | 1 | 0 | 3 |
| Switzerland | 19 | 1 | 0 | 3 |
| Greece | 20 | 1 | 0 | 3 |
| Israel | 21 | 1 | 0 | 3 |
| Norway | 22 | 1 | 0 | 3 |
| Sweden | 23 | 1 | 0 | 3 |
| Bulgaria | 24 | 1 | 0 | 3 |
| Romania | 25 | 1 | 0 | 3 |
| Azerbaijan | 26 | 1 | 0 | 3 |
| Kazakhstan | 27 | 1 | 0 | 3 |
| Hungary | 28 | 1 | 0 | 3 |
| Belarus | 29 | 1 | 0 | 3 |
| Poland | 30 | 1 | 0 | 3 |
| Slovenia | 31 | 1 | 0 | 3 |
| Slovakia | 32 | 1 | 0 | 3 |
| Liechtenstein | 33 | 0 | 0 | 1 |
| Lithuania | 34 | 1 | 0 | 3 |
| Luxembourg | 35 | 1 | 0 | 3 |
| Bosnia and Herzegovina | 36 | 1 | 0 | 3 |
| Republic of Ireland | 37 | 1 | 0 | 3 |
| North Macedonia | 38 | 1 | 0 | 3 |
| Armenia | 39 | 1 | 0 | 3 |
| Latvia | 40 | 1 | 0 | 3 |
| Albania | 41 | 1 | 0 | 3 |
| Northern Ireland | 42 | 1 | 0 | 3 |
| Georgia | 43 | 1 | 0 | 3 |
| Finland | 44 | 1 | 0 | 3 |
| Moldova | 45 | 1 | 0 | 3 |
| Malta | 46 | 1 | 0 | 3 |
| Faroe Islands | 47 | 1 | 0 | 3 |
| Kosovo | 48 | 1 | 0 | 3 |
| Gibraltar | 49 | 1 | 0 | 3 |
| Montenegro | 50 | 1 | 0 | 3 |
| Wales | 51 | 1 | 0 | 2 |
| Iceland | 52 | 1 | 0 | 2 |
| Estonia | 53 | 1 | 0 | 2 |
| Andorra | 54 | 1 | 0 | 2 |
| San Marino | 55 | 1 | 0 | 2 |
Competition Structure
| Stage | # Teams | New Teams Entering This Round | Teams From Previous Round | Format |
|---|---|---|---|---|
| 1st Qualifying | 66 | 20 F/A cup winners from F/As ranked 36-55, 25 second place teams from F/As ranked 30-55 (except Liechtenstein), 21 third place teams from F/As ranked 29-50 (except Liechtenstein) | None | 33 sets of Home/Away matches, highest aggregate goals advances |
| 2nd Qualifying | 108 | 17 F/A cup winners from F/As ranked 19-35, 14 second place teams from F/As ranked 16-29, 16 third place teams from F/As ranked 13-28, 9 fourth place teams from F/As ranked 7-15, 1 fifth place team from F/A ranked 615 teams eliminated during 2021-2022 UEFACL 1st Qualifying Round, 3 teams eliminated during 2021-2022 UEFACL Preliminary Round | 33 winners from 1st Qualifying Round | 54 sets of Home/Away matches, highest aggregate goals advances |
| 3rd Qualifying | 64 | 2 F/A cup winners from F/As ranked 17-18, 6 third place teams from F/As ranked 7-12, 1 fourth place team from F/A ranked 6, 1 team eliminated during 2021-2022 UEFACL 1st Qualifying Round | 54 winners from 2nd Qualifying Round | 32 sets of Home/Away matches, highest aggregate goals advances |
| Playoff | 44 | 1 fifth place team from F/A ranked 5, 4 sixth place teams from F/As ranked 1-4 (ENG2CUP winners), 8 teams eliminated during 2021-2022 UEFAEL 3rd Qualifying Round, -1 team from F/A ranked 1 (current UEFAEL title holderf) | 32 winners from 3rd Qualifying Round | 22 sets of Home/Away matches, highest aggregate goals advances |
| Group | 32 | 10 teams eliminated during 2021-2022 UEFAEL Playoff Round | 22 winners from Playoff Round | 8 groups of 4 with Home/Away matches against each team in group, top 2 teams with most points (win = 3 pts, draw = 1 pt) in each group advance |
| Preliminary Knockout | 16 | 8 third place teams from 2021-2022 UEFAEL Group Stage, | 8 second place teams from Group Stage | 8 sets of Home/Away matches, highest aggregate goals advances |
| Round of 16 | 16 | None | 8 winners from Group Stage, 8 winners from Preliminary Knockout Round | 8 sets of Home/Away matches, highest aggregate goals advances |
| Quarterfinals | 8 | None | 8 winners from Round of 16 | 4 sets of Home/Away matches, highest aggregate goals advances |
| Semifinals | 4 | None | 4 winners from Quarterfinals | 2 sets of Home/Away matches, highest aggregate goals advances |
| Final | 2 | None | 2 winners from Semifinals | 1 match played at a neutral site |
Final
| Date | Home | Status | Road | Venue | ||||
Wed - 25 May 2022
Semifinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Leicester City (ENG1) | 12 | AS Roma (ITA1) |
| 28.04.22 |  | 11 | AS Roma | King Power Stadium |
| 05.05.22 | | 10 | Leicester City | Stadio Olimpico (Roma) |
| Aggregate | Feyenoord (NED1) | 32 | Marseille (FRA1) |
Quarterfinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Feyenoord (NED1) | 64 | SK Slavia Praha (CZE1) |
| 07.04.22 |  | 33 | SK Slavia Praha | Stadion Feijenoord |
| 14.04.22 | | 13 | Feyenoord | Sinobo Stadium |
| Aggregate | FK Bodø/Glimt (NOR1) | 25 | AS Roma (ITA1) |
| 07.04.22 |  | 21 | AS Roma | Aspmyra Stadion |
| 14.04.22 | | 40 | FK Bodø/Glimt | Stadio Olimpico (Roma) |
| Aggregate | Marseille (FRA1) | 31 | PAOK FC (GRE1) |
| Aggregate | Leicester City (ENG1) | 21 | PSV Eindhoven (NED1) |
| 07.04.22 | | 00 | PSV Eindhoven | King Power Stadium |
| 14.04.22 | | 12 | Leicester City | Philips Stadion |
Round of 16
| Date | Home | Status | Road | Venue | ||||
| Aggregate | PAOK FC (GRE1) | 31 | KAA Gent (BEL1) |
| Aggregate | Vitesse Arnhem (NED1) | 12 | AS Roma (ITA1) |
| 10.03.22 |  | 01 | AS Roma | Gelredome |
| 17.03.22 | | 11 | Vitesse Arnhem | Stadio Olimpico (Roma) |
| Aggregate | SK Slavia Praha (CZE1) | 75 | LASK Linz (AUT1) |
| 10.03.22 | | 41 | LASK Linz | Sinobo Stadium |
| 17.03.22 | | 43 | SK Slavia Praha | NV Arena |
| Aggregate | FK Partizan (SRB1) | 38 | Feyenoord (NED1) |
| 10.03.22 |  | 25 | Feyenoord | Stadion Partizana |
| 17.03.22 | | 31 | FK Partizan | Stadion Feijenoord |
| Aggregate | Marseille (FRA1) | 42 | FC Basel (SUI1) |
| Aggregate | Leicester City (ENG1) | 32 | Stade Rennais FC (FRA1) |
| 10.03.22 | | 20 | Stade Rennais FC | King Power Stadium |
| 17.03.22 | | 21 | Leicester City | Roazhon Park |
| Aggregate | PSV Eindhoven (NED1) | 84 | FC København (DEN1) |
| 10.03.22 | | 44 | FC København | Philips Stadion |
| 17.03.22 | | 04 | PSV Eindhoven | Parken Stadium |
| Aggregate | FK Bodø/Glimt (NOR1) | 43 | AZ Alkmaar (NED1) |
| 10.03.22 | | 21 | AZ Alkmaar | Aspmyra Stadion |
| 17.03.22 | | 22 | FK Bodø/Glimt | AFAS Stadion |
Preliminary Knockout Stage
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Fenerbahçe (TUR1) | 46 | SK Slavia Praha (CZE1) |
| 17.02.22 |  | 23 | SK Slavia Praha | Ülker Stadyumu Fenerbahçe Şükrü Saracoğlu Spor Kompleksi |
| 24.02.22 | | 32 | Fenerbahçe | Sinobo Stadium |
| Aggregate | FC Midtjylland (DEN1) | 22 | PAOK FC (GRE1) |
| 17.02.22 |  | 10 | PAOK FC | MCH Arena |
| 24.02.22 | | 21 | FC Midtjylland | Toumba Stadium | ||
| PAOK FC advances on PKs (5-3) | ||||||
| Aggregate | PSV Eindhoven (NED1) | 21 | Maccabi Tel Aviv (ISR1) |
| 17.02.22 | | 10 | Maccabi Tel Aviv | Philips Stadion |
| 24.02.22 | | 11 | PSV Eindhoven | Bloomfield Stadium |
| Aggregate | Rapid Wien (AUT1) | 23 | Vitesse Arnhem (NED1) |
| 17.02.22 |  | 21 | Vitesse Arnhem | Allianz Stadion (Wien) |
| 24.02.22 | | 20 | Rapid Wien | Gelredome |
| Aggregate | Marseille (FRA1) | 61 | Qarabağ FK (AZE1) |
| 17.02.22 |  | 31 | Qarabağ FK | Orange Vélodrome |
| 24.02.22 | | 03 | Marseille | Tofiq Bahramov Stadium |
| Aggregate | Leicester City (ENG1) | 72 | Randers FC (DEN1) |
| 17.02.22 | | 41 | Randers FC | King Power Stadium |
| 24.02.22 | | 13 | Leicester City | Cepheus Park Randers |
| Aggregate | Celtic (SCO1) | 15 | FK Bodø/Glimt (NOR1) |
| 17.02.22 |  | 13 | FK Bodø/Glimt | Celtic Park |
| 24.02.22 | | 20 | Celtic | Aspmyra Stadion |
| Aggregate | Sparta Praha (CZE1) | 13 | FK Partizan (SRB1) |
| 17.02.22 |  | 01 | FK Partizan | Generali Česká pojišťovna Arena |
| 24.02.22 | | 21 | Sparta Praha | Stadion Partizana |
Group Stage
| Group A | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | LASK Linz (AUT1) | 6 | 5 -1-0 | 16 | - | 12 | 1 | 11 | 3 | 2 -1-0 | 7 | 6 | 1 | 5 | 3 | 3 -0-0 | 9 | 6 | 0 | 6 |
| 2 | Maccabi Tel Aviv (ISR1) | 6 | 3 -2-1 | 11 | - | 14 | 4 | 10 | 3 | 2 -0-1 | 6 | 7 | 2 | 5 | 3 | 1 -2-0 | 5 | 7 | 2 | 5 |
| 3 | HJK (FIN1) | 6 | 2 -0-4 | 6 | - | 5 | 15 | -10 | 3 | 1 -0-2 | 3 | 1 | 7 | -6 | 3 | 1 -0-2 | 3 | 4 | 8 | -4 |
| 4 | Alashkert FC (ARM1) | 6 | 0 -1-5 | 1 | - | 4 | 15 | -11 | 3 | 0 -1-2 | 1 | 3 | 8 | -5 | 3 | 0 -0-3 | 0 | 1 | 7 | -6 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 14.09.21 | | 41 | Alashkert FC | Bloomfield Stadium |
| 30.09.21 | | 24 | HJK | Republican Stadium |
| 11 | Maccabi Tel Aviv | Wörthersee Stadion |
| 21.10.21 | | 03 | LASK Linz | Republican Stadium |
| 05 | Maccabi Tel Aviv | Bolt Arena |
| 04.11.21 | | 30 | HJK | Bloomfield Stadium |
| 20 | Alashkert FC | Wörthersee Stadion |
| 25.11.21 | | 10 | Alashkert FC | Bolt Arena |
| 01 | LASK Linz | Bloomfield Stadium |
| 09.12.21 | | 11 | Maccabi Tel Aviv | Republican Stadium |
| Group B | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | KAA Gent (BEL1) | 6 | 4 -1-1 | 13 | - | 6 | 2 | 4 | 3 | 2 -1-0 | 7 | 4 | 1 | 3 | 3 | 2 -0-1 | 6 | 2 | 1 | 1 |
| 2 | FK Partizan (SRB1) | 6 | 2 -2-2 | 8 | - | 6 | 4 | 2 | 3 | 1 -1-1 | 4 | 3 | 2 | 1 | 3 | 1 -1-1 | 4 | 3 | 2 | 1 |
| 3 | Anorthosis Famagusta (CYP1) | 6 | 1 -3-2 | 6 | - | 6 | 9 | -3 | 3 | 1 -1-1 | 4 | 3 | 4 | -1 | 3 | 0 -2-1 | 2 | 3 | 5 | -2 |
| 4 | FC Flora (EST1) | 6 | 1 -2-3 | 5 | - | 5 | 8 | -3 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 | 3 | 0 -1-2 | 1 | 2 | 5 | -3 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
 | 02 | FK Partizan | Neo GSP Stadium |
| 30.09.21 |  | 20 | Anorthosis Famagusta | Ghelamco Arena |
| 20 | FC Flora | Stadion Partizana |
| 21.10.21 | | 22 | FC Flora | Neo GSP Stadium |
| 01 | KAA Gent | Stadion Partizana |
| 04.11.21 | | 22 | Anorthosis Famagusta | A Le Coq Arena |
| 11 | FK Partizan | Ghelamco Arena |
| 25.11.21 | | 10 | FK Partizan | A Le Coq Arena |
| 10 | KAA Gent | Neo GSP Stadium |
| 11 | Anorthosis Famagusta | Stadion Partizana |
| Group C | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | AS Roma (ITA1) | 6 | 4 -1-1 | 13 | - | 18 | 11 | 7 | 3 | 2 -1-0 | 7 | 11 | 3 | 8 | 3 | 2 -0-1 | 6 | 7 | 8 | -1 |
| 2 | FK Bodø/Glimt (NOR1) | 6 | 3 -3-0 | 12 | - | 14 | 5 | 9 | 3 | 3 -0-0 | 9 | 11 | 2 | 9 | 3 | 0 -3-0 | 3 | 3 | 3 | 0 |
| 3 | FC Zorya Luhansk (UKR1) | 6 | 2 -1-3 | 7 | - | 5 | 11 | -6 | 3 | 1 -1-1 | 4 | 3 | 4 | -1 | 3 | 1 -0-2 | 3 | 2 | 7 | -5 |
| 4 | CSKA Sofia (BUL1) | 6 | 0 -1-5 | 1 | - | 3 | 13 | -10 | 3 | 0 -1-2 | 1 | 2 | 4 | -2 | 3 | 0 -0-3 | 0 | 1 | 9 | -8 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 16.09.21 | | 51 | CSKA Sofia | Stadio Olimpico (Roma) |
| 31 | FC Zorya Luhansk | Aspmyra Stadion |
| 30.09.21 | | 03 | AS Roma | Slavutych-Arena |
| 00 | FK Bodø/Glimt | Stadion Vasil Levski |
| 21.10.21 | | 61 | AS Roma | Aspmyra Stadion |
| 01 | FC Zorya Luhansk | Stadion Vasil Levski |
| 04.11.21 | | 20 | CSKA Sofia | Slavutych-Arena |
| 22 | FK Bodø/Glimt | Stadio Olimpico (Roma) |
| 25.11.21 | | 40 | FC Zorya Luhansk | Stadio Olimpico (Roma) |
| 20 | CSKA Sofia | Aspmyra Stadion |
| 09.12.21 | | 11 | FK Bodø/Glimt | Slavutych-Arena |
| 23 | AS Roma | Stadion Vasil Levski |
| Group D | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | AZ Alkmaar (NED1) | 6 | 4 -2-0 | 14 | - | 8 | 3 | 5 | 3 | 3 -0-0 | 9 | 4 | 0 | 4 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 |
| 2 | Randers FC (DEN1) | 6 | 1 -4-1 | 7 | - | 9 | 9 | 0 | 3 | 1 -2-0 | 5 | 6 | 5 | 1 | 3 | 0 -2-1 | 2 | 3 | 4 | -1 |
| 3 | FK Baumit Jablonec (CZE1) | 6 | 1 -3-2 | 6 | - | 6 | 8 | -2 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 | 3 | 0 -1-2 | 1 | 2 | 5 | -3 |
| 4 | CFR Cluj-Napoca (ROU1) | 6 | 1 -1-4 | 4 | - | 4 | 7 | -3 | 3 | 1 -1-1 | 4 | 3 | 2 | 1 | 3 | 0 -0-3 | 0 | 1 | 5 | -4 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 16.09.21 |  | 10 | CFR Cluj-Napoca | Stadion Střelnice (Jablonec nad Nisou) |
| 22 | AZ Alkmaar | Cepheus Park Randers |
| 30.09.21 | | 10 | FK Baumit Jablonec | AFAS Stadion |
| 11 | Randers FC | Stadionul Dr Constantin Rădelescu |
| 21.10.21 | | 22 | Randers FC | Stadion Střelnice (Jablonec nad Nisou) |
| 01 | AZ Alkmaar | Stadionul Dr Constantin Rădelescu |
| 04.11.21 | | 20 | CFR Cluj-Napoca | AFAS Stadion |
| 22 | FK Baumit Jablonec | Cepheus Park Randers |
| 25.11.21 | | 11 | AZ Alkmaar | Stadion Střelnice (Jablonec nad Nisou) |
| 21 | CFR Cluj-Napoca | Cepheus Park Randers |
| 09.12.21 | | 10 | Randers FC | AFAS Stadion |
| 20 | FK Baumit Jablonec | Stadionul Dr Constantin Rădelescu |
| Group E | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Feyenoord (NED1) | 6 | 4 -2-0 | 14 | - | 11 | 6 | 5 | 3 | 3 -0-0 | 9 | 7 | 3 | 4 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 |
| 2 | SK Slavia Praha (CZE1) | 6 | 2 -2-2 | 8 | - | 8 | 7 | 1 | 3 | 2 -1-0 | 7 | 6 | 3 | 3 | 3 | 0 -1-2 | 1 | 2 | 4 | -2 |
| 3 | 1. FC Union Berlin (GER1) | 6 | 2 -1-3 | 7 | - | 8 | 9 | -1 | 3 | 1 -1-1 | 4 | 5 | 3 | 2 | 3 | 1 -0-2 | 3 | 3 | 6 | -3 |
| 4 | Maccabi Haifa (ISR1) | 6 | 1 -1-4 | 4 | - | 2 | 7 | -5 | 3 | 1 -1-1 | 4 | 1 | 1 | 0 | 3 | 0 -0-3 | 0 | 1 | 6 | -5 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 14.09.21 |  | 00 | Feyenoord | Sammey Ofer Stadium |
| 16.09.21 | | 31 | 1. FC Union Berlin | Sinobo Stadium |
| 30.09.21 | | 21 | SK Slavia Praha | Stadion Feijenoord |
| 30 | Maccabi Haifa | Olympiastadion (Berlin) |
| 21.10.21 | | 31 | 1. FC Union Berlin | Stadion Feijenoord |
| 10 | SK Slavia Praha | Sammey Ofer Stadium |
| 04.11.21 | | 10 | Maccabi Haifa | Sinobo Stadium |
| 12 | Feyenoord | Olympiastadion (Berlin) |
| 25.11.21 | | 22 | Feyenoord | Sinobo Stadium |
| 01 | 1. FC Union Berlin | Sammey Ofer Stadium |
| 09.12.21 | | 21 | Maccabi Haifa | Stadion Feijenoord |
| 11 | SK Slavia Praha | Olympiastadion (Berlin) |
| Group F | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | FC København (DEN1) | 6 | 5 -0-1 | 15 | - | 15 | 5 | 10 | 3 | 2 -0-1 | 6 | 6 | 3 | 3 | 3 | 3 -0-0 | 9 | 9 | 2 | 7 |
| 2 | PAOK FC (GRE1) | 6 | 3 -2-1 | 11 | - | 8 | 4 | 4 | 3 | 1 -1-1 | 4 | 4 | 3 | 1 | 3 | 2 -1-0 | 7 | 4 | 1 | 3 |
| 3 | ŠK Slovan Bratislava (SVK1) | 6 | 2 -2-2 | 8 | - | 8 | 7 | 1 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 | 3 | 1 -1-1 | 4 | 5 | 4 | 1 |
| 4 | Lincoln Red Imps FC (GIB1) | 6 | 0 -0-6 | 0 | - | 2 | 17 | -15 | 3 | 0 -0-3 | 0 | 1 | 10 | -9 | 3 | 0 -0-3 | 0 | 1 | 7 | -6 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 16.09.21 |  | 13 | FC København | Štadión Tehelné pole |
 | 02 | PAOK FC | Victoria Stadium (Gibraltar) |
| 30.09.21 | | 11 | ŠK Slovan Bratislava | Toumba Stadium |
| 31 | Lincoln Red Imps FC | Parken Stadium |
| 21.10.21 | | 12 | PAOK FC | Parken Stadium |
| 20 | Lincoln Red Imps FC | Štadión Tehelné pole |
| 04.11.21 | | 14 | ŠK Slovan Bratislava | Victoria Stadium (Gibraltar) |
| 12 | FC København | Toumba Stadium |
| 25.11.21 | | 00 | PAOK FC | Štadión Tehelné pole |
| 04 | FC København | Victoria Stadium (Gibraltar) |
| 09.12.21 | | 20 | Lincoln Red Imps FC | Toumba Stadium |
| 20 | ŠK Slovan Bratislava | Parken Stadium |
| Group G | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Stade Rennais FC (FRA1) | 5 | 3 -2-0 | 11 | - | 10 | 7 | 3 | 3 | 1 -2-0 | 5 | 6 | 5 | 1 | 2 | 2 -0-0 | 6 | 4 | 2 | 2 |
| 2 | Vitesse Arnhem (NED2) | 6 | 3 -1-2 | 10 | - | 12 | 9 | 3 | 3 | 2 -0-1 | 6 | 5 | 3 | 2 | 3 | 1 -1-1 | 4 | 7 | 6 | 1 |
| 3 | Tottenham (ENG1) | 5 | 2 -1-2 | 7 | - | 11 | 8 | 3 | 2 | 2 -0-0 | 6 | 8 | 3 | 5 | 3 | 0 -1-2 | 1 | 3 | 5 | -2 |
| 4 | NŠ Mura (SVN1) | 6 | 1 -0-5 | 3 | - | 5 | 14 | -9 | 3 | 1 -0-2 | 3 | 3 | 5 | -2 | 3 | 0 -0-3 | 0 | 2 | 9 | -7 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 16.09.21 | | 22 | Tottenham | Roazhon Park |
 | 02 | Vitesse Arnhem | Stadion Ljudski VRT |
| 12 | Stade Rennais FC | Gelredome |
| 21.10.21 | | 12 | Stade Rennais FC | Mestni Štadion Fazanerija (Murska Sobota) |
| 10 | Tottenham | Gelredome |
| 04.11.21 | | 10 | NŠ Mura | Roazhon Park |
| 32 | Vitesse Arnhem | Tottenham Hotspur Stadium |
| 25.11.21 | | 33 | Vitesse Arnhem | Roazhon Park |
| 09.12.21 | | PSPD | Stade Rennais FC | Tottenham Hotspur Stadium |
| 31 | NŠ Mura | Gelredome |
| Group H | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | FC Basel (SUI1) | 6 | 4 -2-0 | 14 | - | 14 | 6 | 8 | 3 | 3 -0-0 | 9 | 10 | 3 | 7 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 |
| 2 | Qarabağ FK (AZE1) | 6 | 3 -2-1 | 11 | - | 10 | 8 | 2 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 | 3 | 2 -0-1 | 6 | 6 | 5 | 1 |
| 3 | AC Omonia Nicosia (CYP1) | 6 | 0 -4-2 | 4 | - | 5 | 10 | -5 | 3 | 0 -2-1 | 2 | 2 | 5 | -3 | 3 | 0 -2-1 | 2 | 3 | 5 | -2 |
| 4 | FC Kairat Almaty (KAZ1) | 6 | 0 -2-4 | 2 | - | 6 | 11 | -5 | 3 | 0 -1-2 | 1 | 3 | 5 | -2 | 3 | 0 -1-2 | 1 | 3 | 6 | -3 |
Round of 16 Playoff | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 16.09.21 |  | 00 | AC Omonia Nicosia | Ortalıq Stadion (Almatı) |
| 00 | FC Basel | Bakı Olympiya Stadionu |
| 30.09.21 | | 42 | FC Kairat Almaty | St Jakob Park |
| 14 | Qarabağ FK | Neo GSP Stadium |
| 21.10.21 | | 21 | FC Kairat Almaty | Tofiq Bahramov Stadium |
| 31 | AC Omonia Nicosia | St Jakob Park |
| 04.11.21 | | 12 | Qarabağ FK | Ortalıq Stadion (Almatı) |
| 11 | FC Basel | Neo GSP Stadium |
| 25.11.21 | | 23 | FC Basel | Ortalıq Stadion (Almatı) |
| 22 | AC Omonia Nicosia | Tofiq Bahramov Stadium |
| 09.12.21 | | 30 | Qarabağ FK | St Jakob Park |
| 00 | FC Kairat Almaty | Neo GSP Stadium |
Playoff Stage
| Date | Home | Status | Road | Venue | ||||
| Aggregate | FC Shakhter Karagandy (KAZ1) | 14 | Maccabi Tel Aviv (ISR1) |
| 19.08.21 |  | 12 | Maccabi Tel Aviv | Astana Arena |
| 26.08.21 | | 20 | FC Shakhter Karagandy | Bloomfield Stadium |
| Aggregate | FC Flora (EST1) | 52 | Shamrock Rovers (IRL1) |
| 19.08.21 | | 42 | Shamrock Rovers | A Le Coq Arena |
| 26.08.21 | | 01 | FC Flora | Tallaght Stadium |
| Aggregate | Qarabağ FK (AZE1) | 41 | Aberdeen FC (SCO1) |
| 19.08.21 | | 10 | Aberdeen FC | Tofiq Bahramov Stadium |
| 26.08.21 | | 13 | Qarabağ FK | Pittodrie Stadium |
| Aggregate | KuPS (FIN1) | 04 | 1. FC Union Berlin (GER1) |
| 19.08.21 |  | 04 | 1. FC Union Berlin | Helsingin Olympiastadion |
| 26.08.21 | | 00 | KuPS | Olympiastadion (Berlin) |
| Aggregate | Raków Częstochowa (POL1) | 13 | KAA Gent (BEL1) |
| 19.08.21 |  | 10 | KAA Gent | Stadion Miejski w Bielsku-Bialej |
| 26.08.21 | | 30 | Raków Częstochowa | Ghelamco Arena |
| Aggregate | VMFD Žalgiris Vilnius (LTU1) | 23 | FK Bodø/Glimt (NOR1) |
| 19.08.21 |  | 22 | FK Bodø/Glimt | LFF Stadium |
| 26.08.21 | | 10 | VMFD Žalgiris Vilnius | Aspmyra Stadion |
| Aggregate | Neftçi Baku PFK (AZE1) | 37 | Maccabi Haifa (ISR1) |
| 19.08.21 |  | 33 | Maccabi Haifa | Bakcell Arena |
| 26.08.21 | | 40 | Neftçi Baku PFK | Sammey Ofer Stadium |
| Aggregate | Riga FC (LVA1) | 24 | Lincoln Red Imps FC (GIB1) |
| 19.08.21 |  | 11 | Lincoln Red Imps FC | Skonto Stadions |
| 26.08.21 | | 31 | Riga FC | Victoria Stadium (Gibraltar) |
| Aggregate | FC Viktoria Plzeň (CZE1) | 23 | CSKA Sofia (BUL1) |
| 19.08.21 |  | 20 | CSKA Sofia | Doosan Aréna |
| 26.08.21 | | 30 | FC Viktoria Plzeň | Stadion Vasil Levski |
| Aggregate | LASK Linz (AUT1) | 31 | St Johnstone FC (SCO1) |
| 19.08.21 | | 11 | St Johnstone FC | Wörthersee Stadion |
| 26.08.21 | | 02 | LASK Linz | McDiarmid Park |
| Aggregate | Hapoel Be'er Sheva FC (ISR1) | 13 | Anorthosis Famagusta (CYP1) |
| 19.08.21 |  | 00 | Anorthosis Famagusta | Yaakov Turner Toto Stadium |
| 26.08.21 | | 31 | Hapoel Be'er Sheva FC | Stadio Antonis Papadopoulos |
| Aggregate | CS Fola Esch (LUX1) | 27 | FC Kairat Almaty (KAZ1) |
| 19.08.21 |  | 14 | FC Kairat Almaty | Stade Josy Barthel |
| 26.08.21 | | 31 | CS Fola Esch | Ortalıq Stadion (Almatı) |
| Aggregate | FC Basel (SUI1) | 44 | Hammarby IF (SWE1) |
| 19.08.21 | | 31 | Hammarby IF | St Jakob Park |
| 26.08.21 | | 31 | FC Basel | Tele2 Arena | ||
| FC Basel advances on PKs (4-3) | ||||||
| Aggregate | Trabzonspor (TUR1) | 15 | AS Roma (ITA1) |
| 19.08.21 |  | 12 | AS Roma | Medical Park Stadyumu |
| 26.08.21 | | 30 | Trabzonspor | Stadio Olimpico (Roma) |
| Aggregate | FK Baumit Jablonec (CZE1) | 81 | MŠK Žilina (SVK1) |
| 19.08.21 | | 51 | MŠK Žilina | Stadion Střelnice (Jablonec nad Nisou) |
| 26.08.21 | | 03 | FK Baumit Jablonec | Štadión pod Dubňom |
| Aggregate | Stade Rennais FC (FRA1) | 51 | Rosenborg BK (NOR1) |
| 19.08.21 | | 20 | Rosenborg BK | Roazhon Park |
| 26.08.21 | | 13 | Stade Rennais FC | Lerkendal Stadion |
| Aggregate | Anderlecht (BEL1) | 45 | Vitesse Arnhem (NED1) |
| 19.08.21 |  | 33 | Vitesse Arnhem | Lotto Park |
| 26.08.21 | | 21 | Anderlecht | Gelredome |
| Aggregate | PAOK FC (GRE1) | 31 | HNK Rijeka (CRO1) |
| 19.08.21 | | 11 | HNK Rijeka | Toumba Stadium |
| 26.08.21 | | 02 | PAOK FC | Stadion HNK Rijeka |
| Aggregate | Feyenoord (NED1) | 63 | IF Elfsborg (SWE1) |
| 19.08.21 | | 50 | IF Elfsborg | Stadion Feijenoord |
| 26.08.21 | | 31 | Feyenoord | Borås Arena |
| Aggregate | Sivasspor (TUR1) | 17 | FC København (DEN1) |
| 19.08.21 |  | 12 | FC København | Yeni Sivas 4 Eylül Stadyumu |
| 26.08.21 | | 50 | Sivasspor | Parken Stadium |
| Aggregate | FC Paços de Ferreira (POR1) | 13 | Tottenham (ENG1) |
| 19.08.21 |  | 10 | Tottenham | Estádio da Capital do Móvel |
| 26.08.21 | | 30 | FC Paços de Ferreira | Tottenham Hotspur Stadium |
| Aggregate | CD Santa Clara (POR1) | 23 | FK Partizan (SRB1) |
| 19.08.21 |  | 21 | FK Partizan | Estádio de São Miguel |
| 26.08.21 | | 20 | CD Santa Clara | Stadion Partizana |
3rd Qualifying Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Linfield FC (NIR1) | 24 | CS Fola Esch (LUX1) |
| 03.08.21 |  | 12 | CS Fola Esch | Windsor Park (Belfast) |
| 12.08.21 | | 21 | Linfield FC | Stade Josy Barthel |
| Aggregate | Bohemians FC (IRL1) | 23 | PAOK FC (GRE1) |
| 03.08.21 |  | 21 | PAOK FC | Aviva Stadium |
| 12.08.21 | | 20 | Bohemians FC | Toumba Stadium |
| Aggregate | KuPS (FIN1) | 54 | FC Astana (KAZ1) |
| Aggregate | PFC Lokomotiv Plovdiv (BUL1) | 35 | FC København (DEN1) |
| 05.08.21 |  | 11 | FC København | Stadion Lokomotiv (Plovdiv) |
| 12.08.21 | | 42 | PFC Lokomotiv Plovdiv | Parken Stadium |
| Aggregate | PFC Sochi (RUS1) | 33 | FK Partizan (SRB1) |
| 05.08.21 |  | 11 | FK Partizan | Olimpiyskiy Stadion Fisht |
| 12.08.21 | | 22 | PFC Sochi | Stadion Partizana | ||
| FK Partizan advances on PKs (4-2) | ||||||
| Aggregate | FC Tobol (KAZ1) | 06 | MŠK Žilina (SVK1) |
| 05.08.21 |  | 01 | MŠK Žilina | Astana Arena |
| 12.08.21 | | 50 | FC Tobol | Štadión pod Dubňom |
| Aggregate | IF Elfsborg (SWE1) | 52 | FK Velež Mostar (BIH1) |
| 05.08.21 | | 11 | FK Velež Mostar | Borås Arena |
| 12.08.21 | | 14 | IF Elfsborg | Stadion Grbavica |
| Aggregate | Maccabi Haifa (ISR1) | 73 | HB Tórshavn (FRO1) |
| 05.08.21 | | 72 | HB Tórshavn | Sammey Ofer Stadium |
| 12.08.21 | | 10 | Maccabi Haifa | Tórsvøllur |
| Aggregate | Riga FC (LVA1) | 42 | Hibernians FC (MLT1) |
| 05.08.21 | | 01 | Hibernians FC | Daugava Stadions (Rīga) |
| 12.08.21 | | 14 | Riga FC | MFA Centenary Stadium (Ta'Qali) |
| Aggregate | FC Dinamo Batumi (GEO1) | 23 | Sivasspor (TUR1) |
| 05.08.21 |  | 12 | Sivasspor | Adjarabet Arena |
| 12.08.21 | | 11 | FC Dinamo Batumi | Yeni Sivas 4 Eylül Stadyumu |
| Aggregate | CSKA Sofia (BUL1) | 53 | NK Osijek (CRO1) |
| 05.08.21 | | 42 | NK Osijek | Stadion Vasil Levski |
| 12.08.21 | | 11 | CSKA Sofia | Stadion Gradski vrt |
| Aggregate | AEL Limassol (CYP1) | 12 | Qarabağ FK (AZE1) |
| 05.08.21 |  | 11 | Qarabağ FK | AEK Arena - George Karapatakis |
| 12.08.21 | | 10 | AEL Limassol | Tofiq Bahramov Stadium |
| Aggregate | Rosenborg BK (NOR1) | 82 | NK Domžale (SVN1) |
| 05.08.21 | | 61 | NK Domžale | Lerkendal Stadion |
| 10.08.21 | | 12 | Rosenborg BK | Stadion Stožice |
| Aggregate | KF Laçi (ALB1) | 15 | Anderlecht (BEL1) |
| 05.08.21 |  | 03 | Anderlecht | Elbasan Arena |
| 12.08.21 | | 21 | KF Laçi | Lotto Park |
| Aggregate | Vitesse Arnhem (NED1) | 43 | Dundalk FC (IRL1) |
| 05.08.21 | | 22 | Dundalk FC | Gelredome |
| 12.08.21 | | 12 | Vitesse Arnhem | Tallaght Stadium |
| Aggregate | FK Vojvodina Novi Sad (SRB1) | 17 | LASK Linz (AUT1) |
| 05.08.21 |  | 01 | LASK Linz | Stadion Karađorđe |
| 12.08.21 | | 61 | FK Vojvodina Novi Sad | Wörthersee Stadion |
| Aggregate | Trabzonspor (TUR1) | 44 | Molde FK (NOR1) |
| 05.08.21 | | 33 | Molde FK | Medical Park Stadyumu |
| 12.08.21 | | 11 | Trabzonspor | Aker Stadion | ||
| Trabzonspor advances on PKs (4-3) | ||||||
| Aggregate | FC Prishtina (KVX1) | 23 | FK Bodø/Glimt (NOR1) |
| 05.08.21 |  | 21 | FK Bodø/Glimt | Stadiumi Fadil Vokrri |
| 12.08.21 | | 20 | FC Prishtina | Aspmyra Stadion |
| Aggregate | FC Paços de Ferreira (POR1) | 41 | Larne FC (NIR1) |
| 05.08.21 | | 40 | Larne FC | Estádio da Capital do Móvel |
| 12.08.21 | | 10 | FC Paços de Ferreira | Inver Park |
| Aggregate | Śląsk Wroclaw (POL1) | 25 | Hapoel Be'er Sheva FC (ISR1) |
| 05.08.21 |  | 21 | Hapoel Be'er Sheva FC | Stadion Miejski (Wrocław) |
| 12.08.21 | | 40 | Śląsk Wroclaw | HaMoshava Stadium |
| Aggregate | FC Kolos Kovalivka (UKR1) | 00 | FC Shakhter Karagandy (KAZ1) |
| 05.08.21 |  | 00 | FC Shakhter Karagandy | Stadion Kovalivka |
| 10.08.21 | | 00 | FC Kolos Kovalivka | Astana Arena |
| Aggregate | FC Spartak Tnrava (SVK1) | 01 | Maccabi Tel Aviv (ISR1) |
| 05.08.21 |  | 00 | Maccabi Tel Aviv | Štadión Antona Malatinského |
| 12.08.21 | | 10 | FC Spartak Tnrava | Bloomfield Stadium |
| Aggregate | FC Luzern (SUI1) | 06 | Feyenoord (NED1) |
| Aggregate | KAA Gent (BEL1) | 32 | FK Rīgas Futbola skola (LVA1) |
| 05.08.21 | | 22 | FK Rīgas Futbola skola | Ghelamco Arena |
| 12.08.21 | | 01 | KAA Gent | Daugava Stadions (Rīga) |
| Aggregate | Hibernian FC (SCO1) | 25 | HNK Rijeka (CRO1) |
| 05.08.21 |  | 11 | HNK Rijeka | Easter Road |
| 12.08.21 | | 41 | Hibernian FC | Stadion HNK Rijeka |
| Aggregate | The New Saints (WAL1) | 55 | FC Viktoria Plzeň (CZE1) |
| 05.08.21 |  | 42 | FC Viktoria Plzeň | Cardiff City Stadium |
| 12.08.21 | | 31 | The New Saints | Doosan Aréna | ||
| FC Viktoria Plzeň advances on PKs (4-1) | ||||||
| Aggregate | FK Čukarički (SRB1) | 46 | Hammarby IF (SWE1) |
| 05.08.21 |  | 31 | Hammarby IF | Stadion Partizana |
| 12.08.21 | | 51 | FK Čukarički | Tele2 Arena |
| Aggregate | Shamrock Rovers (IRL1) | 30 | KS Teuta Durrës (ALB1) |
| 05.08.21 | | 10 | KS Teuta Durrës | Tallaght Stadium |
| 12.08.21 | | 02 | Shamrock Rovers | Elbasan Arena |
| Aggregate | Breiðablik UBK (ISL1) | 35 | Aberdeen FC (SCO1) |
| 05.08.21 |  | 23 | Aberdeen FC | Laugardalsvöllur |
| 12.08.21 | | 21 | Breiðablik UBK | Pittodrie Stadium |
| Aggregate | Raków Częstochowa (POL1) | 10 | FK Rubin Kazan (RUS1) |
| 05.08.21 | | 00 | FK Rubin Kazan | Stadion Miejski w Bielsku-Bialej |
| 12.08.21 | | 01 | Raków Częstochowa | Kazan Arena |
| Aggregate | Újpest FC (HUN1) | 16 | FC Basel (SUI1) |
| Aggregate | CD Santa Clara (POR1) | 30 | NK Olimpija Ljubljana (SVN1) |
| 05.08.21 | | 20 | NK Olimpija Ljubljana | Estádio de São Miguel |
| 12.08.21 | | 01 | CD Santa Clara | Stadion Stožice |
2nd Qualifying Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | NK Domžale (SVN1) | 21 | FC Honka (FIN1) |
| 20.07.21 | | 11 | FC Honka | Športni Park (Domžale) |
| 29.07.21 | | 01 | NK Domžale | Bolt Arena |
| Aggregate | FK Kauno Žalgiris (LTU1) | 110 | The New Saints (WAL1) |
| 20.07.21 |  | 05 | The New Saints | Hikvision arena |
| 29.07.21 | | 51 | FK Kauno Žalgiris | Park Hall Stadium |
| Aggregate | FC Prishtina (KVX1) | 65 | Gap Connah's Quay (WAL1) |
| 20.07.21 | | 41 | Gap Connah's Quay | Stadiumi Fadil Vokrri |
| 29.07.21 | | 42 | FC Prishtina | Park Avenue Ground |
| Aggregate | SS Folgore Falciano (SMR1) | 37 | Hibernians FC (MLT1) |
| 20.07.21 |  | 13 | Hibernians FC | Stadio Olimpico di Serravalle |
| 27.07.21 | | 42 | SS Folgore Falciano | MFA Centenary Stadium (Ta'Qali) |
| Aggregate | FK Čukarički (SRB1) | 20 | Sumgayıt FC (AZE1) |
| 21.07.21 | | 00 | Sumgayıt FC | Stadion čukarički |
| 29.07.21 | | 02 | FK Čukarički | Kapital Bank Arena |
| Aggregate | FC Ararat Yerevan (ARM1) | 57 | Śląsk Wroclaw (POL1) |
| 22.07.21 |  | 24 | Śląsk Wroclaw | Gyumri City Stadium |
| 29.07.21 | | 33 | FC Ararat Yerevan | Stadion Miejski (Wrocław) |
| Aggregate | FC Astana (KAZ1) | 32 | Aris FC (GRE1) |
| Aggregate | AEL Limassol (CYP1) | 20 | KF Vllaznia Shkodër (ALB1) |
| 22.07.21 | | 10 | KF Vllaznia Shkodër | Tsirion Stadium |
| 29.07.21 | | 01 | AEL Limassol | Stadiumi Loro Boriçi |
| Aggregate | FH Hafnarfjarðar (ISL1) | 16 | Rosenborg BK (NOR1) |
| 22.07.21 |  | 02 | Rosenborg BK | Kaplakrikavöllur |
| 29.07.21 | | 41 | FH Hafnarfjarðar | Lerkendal Stadion |
| Aggregate | FK Panevėžys (LTU1) | 02 | FK Vojvodina Novi Sad (SRB1) |
| 22.07.21 |  | 01 | FK Vojvodina Novi Sad | Aukštaitija Stadium |
| 29.07.21 | | 10 | FK Panevėžys | Stadion Karađorđe |
| Aggregate | KuPS (FIN1) | 54 | FC Vorskla Poltava (UKR1) |
| 22.07.21 | | 22 | FC Vorskla Poltava | Kuopion Keskuskentän tekonurmi |
| 29.07.21 | | 23 | KuPS | Stadion Oleksiy Butovsky Vorskla |
| Aggregate | FK Rīgas Futbola skola (LVA1) | 50 | Puskás Akadémia FC (HUN1) |
| 22.07.21 | | 30 | Puskás Akadémia FC | Slokas Stadionā |
| 29.07.21 | | 02 | FK Rīgas Futbola skola | Pancho Arena |
| Aggregate | NK Olimpija Ljubljana (SVN1) | 11 | Birkirkara FC (MLT1) |
| 22.07.21 | | 10 | Birkirkara FC | Športni park Ljubljana |
| 29.07.21 | | 10 | NK Olimpija Ljubljana | MFA Centenary Stadium (Ta'Qali) | ||
| NK Olimpija Ljubljana advances on PKs (5-4) | ||||||
| Aggregate | Qarabağ FK (AZE1) | 10 | FC Ashdod (ISR1) |
| 22.07.21 | | 00 | FC Ashdod | Tofiq Bahramov Stadium |
| 29.07.21 | | 01 | Qarabağ FK | Yud-Alef Stadium |
| Aggregate | Molde FK (NOR1) | 32 | Servette FC (SUI1) |
| 22.07.21 | | 30 | Servette FC | Aker Stadion |
| 29.07.21 | | 20 | Molde FK | Stade de Genéve |
| Aggregate | FK Austria Wien (AUT1) | 23 | Breiðablik UBK (ISL1) |
| 22.07.21 |  | 11 | Breiðablik UBK | Generali Arena (Wien) |
| 29.07.21 | | 21 | FK Austria Wien | Kópavogsvöllur; |
| Aggregate | PFC Sochi (RUS1) | 72 | Keşlə FK (AZE1) |
| Aggregate | FC Dinamo Tbilisi (GEO1) | 27 | Maccabi Haifa (ISR1) |
| 22.07.21 |  | 12 | Maccabi Haifa | Dinamo Arena |
| 29.07.21 | | 51 | FC Dinamo Tbilisi | Sammey Ofer Stadium |
| Aggregate | F91 Dudelange (LUX1) | 04 | Bohemians FC (IRL1) |
| 22.07.21 |  | 01 | Bohemians FC | Stade Jos Nosbaum |
| 29.07.21 | | 30 | F91 Dudelange | Aviva Stadium |
| Aggregate | Hammarby IF (SWE1) | 41 | NK Maribor (SVN1) |
| 22.07.21 | | 31 | NK Maribor | Tele2 Arena |
| 29.07.21 | | 01 | Hammarby IF | Stadion Ljudski VRT |
| Aggregate | IF Elfsborg (SWE1) | 90 | FC Milsami-Ursidos (MDA1) |
| 22.07.21 | | 40 | FC Milsami-Ursidos | Borås Arena |
| 29.07.21 | | 05 | IF Elfsborg | Complexul Sportiv Raional Orhei |
| Aggregate | KF Laçi (ALB1) | 10 | Universitatea Craiova (ROU1) |
| 22.07.21 | | 10 | Universitatea Craiova | Elbasan Arena |
| 29.07.21 | | 00 | KF Laçi | Stadionul Ion Oblemenco |
| Aggregate | KS Teuta Durrës (ALB1) | 32 | Inter Club d'Escaldes (AND1) |
| 22.07.21 | | 02 | Inter Club d'Escaldes | Stadiumi Niko Dovana |
| 27.07.21 | | 03 | KS Teuta Durrës | Estadi Nacional (Andorra la Vella) |
| Aggregate | Riga FC (LVA1) | 30 | FK Shkëndija (MKD1) |
| 22.07.21 | | 20 | FK Shkëndija | Skonto Stadions |
| 29.07.21 | | 01 | Riga FC | Toše Proeski Arena |
| Aggregate | CSKA Sofia (BUL1) | 00 | FK Liepāja (LVA1) |
| 22.07.21 | | 00 | FK Liepāja | Balgarska Armia Stadium |
| 29.07.21 | | 00 | CSKA Sofia | Daugava Stadions (Liepāja) | ||
| CSKA Sofia advances on PKs (3-1) | ||||||
| Aggregate | Apollon Limassol (CYP1) | 35 | MŠK Žilina (SVK1) |
| 22.07.21 |  | 13 | MŠK Žilina | AEK Arena - George Karapatakis |
| 29.07.21 | | 22 | Apollon Limassol | Štadión pod Dubňom |
| Aggregate | Gżira United FC (MLT1) | 03 | HNK Rijeka (CRO1) |
| 22.07.21 |  | 02 | HNK Rijeka | MFA Centenary Stadium (Ta'Qali) |
| 29.07.21 | | 10 | Gżira United FC | Stadion HNK Rijeka |
| Aggregate | FC Dinamo Batumi (GEO1) | 42 | Bate Borisov (BLR1) |
| 22.07.21 | | 01 | Bate Borisov | Batumi Arena |
| 29.07.21 | | 14 | FC Dinamo Batumi | Borisov Arena |
| Aggregate | PFC Lokomotiv Plovdiv (BUL1) | 11 | 1. FC Slovácko (CZE1) |
| 22.07.21 | | 10 | 1. FC Slovácko | Stadion Lokomotiv (Plovdiv) |
| 29.07.21 | | 10 | PFC Lokomotiv Plovdiv | Městský Fotbalový Stadion | ||
| PFC Lokomotiv Plovdiv advances on PKs (3-2) | ||||||
| Aggregate | FK Sūduva Marijampolė (LTU1) | 00 | Raków Częstochowa (POL1) |
| 22.07.21 |  | 00 | Raków Częstochowa | Hikvision arena |
| 29.07.21 | | 00 | FK Sūduva Marijampolė | Stadion Miejski w Bielsku-Bialej |
| Aggregate | FC København (DEN1) | 91 | FC Torpedo-Belaz Zhodino (BLR1) |
| 22.07.21 | | 41 | FC Torpedo-Belaz Zhodino | Parken Stadium |
| 29.07.21 | | 05 | FC København | Central'nyj stadion Kazan' |
| Aggregate | FC Viktoria Plzeň (CZE1) | 42 | FC Dinamo Brest (BLR1) |
| 22.07.21 | | 21 | FC Dinamo Brest | Doosan Aréna |
| 29.07.21 | | 12 | FC Viktoria Plzeň | Football Academy Stadium |
| Aggregate | CS Petrocub Hînceşti (MDA1) | 02 | Sivasspor (TUR1) |
| 22.07.21 |  | 01 | Sivasspor | Stadionul Zimbru |
| 29.07.21 | | 10 | CS Petrocub Hînceşti | Yeni Sivas 4 Eylül Stadyumu |
| Aggregate | HB Tórshavn (FRO1) | 60 | Budućnost Podgorica (MNE1) |
| 22.07.21 | | 40 | Budućnost Podgorica | Gundadalar Stadium |
| 27.07.21 | | 02 | HB Tórshavn | Stadion pod Goricom |
| Aggregate | KF Shkupi 1927 (MKD1) | 05 | CD Santa Clara (POR1) |
| 22.07.21 |  | 03 | CD Santa Clara | Toše Proeski Arena |
| 29.07.21 | | 20 | KF Shkupi 1927 | Estádio de São Miguel |
| Aggregate | FK Arda Kardzhali (BUL1) | 06 | Hapoel Be'er Sheva FC (ISR1) |
| 22.07.21 |  | 02 | Hapoel Be'er Sheva FC | Arena Arda |
| 29.07.21 | | 40 | FK Arda Kardzhali | HaMoshava Stadium |
| Aggregate | FC Basel (SUI1) | 50 | FK Partizani (ALB1) |
| 22.07.21 | | 30 | FK Partizani | St Jakob Park |
| 29.07.21 | | 02 | FC Basel | Elbasan Arena |
| Aggregate | KAA Gent (BEL1) | 42 | Våleranga IF (NOR1) |
| 22.07.21 | | 40 | Våleranga IF | Ghelamco Arena |
| 29.07.21 | | 20 | KAA Gent | Intility Arena |
| Aggregate | FK Sutjeska Nikšić (MNE1) | 13 | Maccabi Tel Aviv (ISR1) |
| 22.07.21 |  | 00 | Maccabi Tel Aviv | DG Arena |
| 29.07.21 | | 31 | FK Sutjeska Nikšić | Bloomfield Stadium |
| Aggregate | FK Velež Mostar (BIH1) | 22 | AEK Athens (GRE1) |
| 22.07.21 | | 21 | AEK Athens | Stadion Grbavica |
| 29.07.21 | | 10 | FK Velež Mostar | Olympic Stadium Spyros Louis | ||
| FK Velež Mostar advances on PKs (3-2) | ||||||
| Aggregate | FC Steaua Bucureşti (ROU1) | 22 | FC Shakhter Karagandy (KAZ1) |
| 22.07.21 |  | 10 | FC Shakhter Karagandy | Arena Naţională |
| 29.07.21 | | 21 | FC Steaua Bucureşti | Republican Stadium | ||
| FC Shakhter Karagandy advances on PKs (5-3) | ||||||
| Aggregate | Larne FC (NIR1) | 32 | Aarhus GF (DEN1) |
| Aggregate | Hibernian FC (SCO1) | 51 | FC Santa Coloma (AND1) |
| 22.07.21 | | 30 | FC Santa Coloma | Easter Road |
| 29.07.21 | | 12 | Hibernian FC | Estadi Nacional (Andorra la Vella) |
| Aggregate | FC Spartak Tnrava (SVK1) | 11 | Sepsi (ROU1) |
| 22.07.21 | | 00 | Sepsi | Štadión Antona Malatinského |
| 29.07.21 | | 11 | FC Spartak Tnrava | Stadionul Municipal (Sfântu Gheorghe) | ||
| FC Spartak Tnrava advances on PKs (4-3) | ||||||
| Aggregate | Aberdeen FC (SCO1) | 53 | BK Häcken (SWE1) |
| 22.07.21 | | 51 | BK Häcken | Pittodrie Stadium |
| 29.07.21 | | 20 | Aberdeen FC | Bravida Arena |
| Aggregate | Linfield FC (NIR1) | 40 | Borac Banja Luka (BIH1) |
| 22.07.21 | | 40 | Borac Banja Luka | Windsor Park (Belfast) |
| 29.07.21 | | 00 | Linfield FC | Banja Luka City Stadium |
| Aggregate | FK Partizan (SRB1) | 30 | FK DAC 1904 Dunajská (SVK1) |
| 22.07.21 | | 10 | FK DAC 1904 Dunajská | Stadion Partizana |
| 29.07.21 | | 02 | FK Partizan | MOL Aréna |
| Aggregate | HNK Hajduk Split (CRO1) | 34 | FC Tobol (KAZ1) |
| 22.07.21 |  | 20 | FC Tobol | Gradski Stadion u Poljudu |
| 29.07.21 | | 41 | HNK Hajduk Split | Ortalıq Stadion (Kostanay) |
| Aggregate | Dundalk FC (IRL1) | 43 | FC Levadia Tallinn (EST1) |
| 22.07.21 | | 22 | FC Levadia Tallinn | Oriel Park |
| 29.07.21 | | 12 | Dundalk FC | A Le Coq Arena |
| Aggregate | Knattspyrnufélagið Valur (ISL1) | 06 | FK Bodø/Glimt (NOR1) |
| 22.07.21 |  | 03 | FK Bodø/Glimt | Origovöllurinn |
| 29.07.21 | | 30 | Knattspyrnufélagið Valur | Aspmyra Stadion |
| Aggregate | KF Drita (KVX1) | 23 | Feyenoord (NED1) |
| Aggregate | MKS Pogón Szczecin (POL1) | 01 | NK Osijek (CRO1) |
| 22.07.21 |  | 00 | NK Osijek | Stadion Miejski im Floriana Krygiera |
| 29.07.21 | | 10 | MKS Pogón Szczecin | Stadion Gradski vrt |
| Aggregate | Újpest FC (HUN1) | 52 | FC Vaduz (SUI2) |
| Aggregate | FC Shakhtyor Salihorsk (BLR1) | 13 | CS Fola Esch (LUX1) |
| 22.07.21 |  | 12 | CS Fola Esch | Diósgyőri Stadion |
| 29.07.21 | | 10 | FC Shakhtyor Salihorsk | Stade émile Mayrisch |
1st Qualifying Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Mosta FC (MLT1) | 34 | FC Spartak Tnrava (SVK1) |
| 06.07.21 |  | 32 | FC Spartak Tnrava | MFA Centenary Stadium (Ta'Qali) |
| 15.07.21 | | 20 | Mosta FC | Štadión Antona Malatinského |
| Aggregate | Mons Calpe SC (GIB1) | 15 | FC Santa Coloma (AND1) |
| 06.07.21 |  | 11 | FC Santa Coloma | Victoria Stadium (Gibraltar) |
| 15.07.21 | | 40 | Mons Calpe SC | Estadi Nacional (Andorra la Vella) |
| Aggregate | FK Podgorica (MNE1) | 13 | KF Laçi (ALB1) |
| 06.07.21 |  | 10 | KF Laçi | DG Arena |
| 15.07.21 | | 30 | FK Podgorica | Elbasan Arena |
| Aggregate | FC Noah (ARM1) | 15 | KuPS (FIN1) |
| Aggregate | FK Sileks Kratovo (MKD1) | 12 | CS Petrocub Hînceşti (MDA1) |
| 08.07.21 |  | 11 | CS Petrocub Hînceşti | Trening centar Petar Miloševski (Skopje) |
| 15.07.21 | | 10 | FK Sileks Kratovo | Stadionul Zimbru |
| Aggregate | FK Liepāja (LVA1) | 52 | FC Struga (MKD1) |
| 08.07.21 | | 11 | FC Struga | Daugava Stadions (Liepāja) |
| 15.07.21 | | 14 | FK Liepāja | Trening centar Petar Miloševski (Skopje) |
| Aggregate | FC Inter Turku (FIN1) | 13 | Puskás Akadémia FC (HUN1) |
| 08.07.21 |  | 11 | Puskás Akadémia FC | Veritas Stadion |
| 15.07.21 | | 20 | FC Inter Turku | Puskás Aréna |
| Aggregate | FK Sūduva Marijampolė (LTU1) | 21 | Valmiera Glass FK (LVA1) |
| 08.07.21 | | 21 | Valmiera Glass FK | Hikvision arena |
| 15.07.21 | | 00 | FK Sūduva Marijampolė | Daugava Stadions (Rīga) |
| Aggregate | FK Rīgas Futbola skola (LVA1) | 65 | KÍ Klaksvík (FRO1) |
| 08.07.21 | | 23 | KÍ Klaksvík | Slokas Stadionā |
| 15.07.21 | | 24 | FK Rīgas Futbola skola | Við Djúpumýrar |
| Aggregate | UE Sant Juliá (AND1) | 11 | Gżira United FC (MLT1) |
| 08.07.21 |  | 00 | Gżira United FC | Estadi Nacional (Andorra la Vella) |
| 15.07.21 | | 11 | UE Sant Juliá | MFA Centenary Stadium (Ta'Qali) | ||
| Gżira United FC advances on PKs (5-3) | ||||||
| Aggregate | FC Honka (FIN1) | 31 | NSÍ Runavik (FRO1) |
| 08.07.21 | | 00 | NSÍ Runavik | Bolt Arena |
| 15.07.21 | | 13 | FC Honka | Svangaskarð |
| Aggregate | FC Levadia Tallinn (EST1) | 42 | St Joseph's FC (GIB1) |
| 08.07.21 | | 31 | St Joseph's FC | A Le Coq Arena |
| 15.07.21 | | 11 | FC Levadia Tallinn | Victoria Stadium (Gibraltar) |
| Aggregate | MŠK Žilina (SVK1) | 63 | FC Dila Gori (GEO1) |
| 08.07.21 | | 51 | FC Dila Gori | Štadión pod Dubňom |
| 15.07.21 | | 21 | MŠK Žilina | Stadioni Tengiz Burjanadze |
| Aggregate | Dundalk FC (IRL1) | 50 | Newtown AFC (WAL1) |
| 08.07.21 | | 40 | Newtown AFC | Oriel Park |
| 13.07.21 | | 01 | Dundalk FC | Park Hall Stadium |
| Aggregate | FC Milsami-Ursidos (MDA1) | 10 | FK Sarajevo (BIH1) |
| 08.07.21 | | 00 | FK Sarajevo | Complexul Sportiv Raional Orhei |
| 15.07.21 | | 01 | FC Milsami-Ursidos | Asim Ferhatović Hase Stadium |
| Aggregate | Racing FC Union (LUX1) | 25 | Breiðablik UBK (ISL1) |
| 08.07.21 |  | 23 | Breiðablik UBK | Stade Josy Barthel |
| 15.07.21 | | 20 | Racing FC Union | Kópavogsvöllur; |
| Aggregate | Glentoran FC (NIR1) | 13 | The New Saints (WAL1) |
| 08.07.21 |  | 11 | The New Saints | The Oval |
| 15.07.21 | | 20 | Glentoran FC | Park Hall Stadium |
| Aggregate | KF Shkupi 1927 (MKD1) | 31 | KF Llapi (KVX1) |
| 08.07.21 | | 20 | KF Llapi | Toše Proeski Arena |
| 15.07.21 | | 11 | KF Shkupi 1927 | Stadiumi Fadil Vokrri |
| Aggregate | FH Hafnarfjarðar (ISL1) | 31 | Sligo Rovers FC (IRL1) |
| 08.07.21 | | 10 | Sligo Rovers FC | Kaplakrikavöllur |
| 15.07.21 | | 12 | FH Hafnarfjarðar | The Showgrounds (Sligo) |
| Aggregate | Fehérvár FC (HUN1) | 13 | FC Ararat Yerevan (ARM1) |
| 08.07.21 |  | 11 | FC Ararat Yerevan | MOL Aréna Sóstó |
| 15.07.21 | | 20 | Fehérvár FC | Gyumri City Stadium |
| Aggregate | NK Domžale (SVN1) | 21 | FC Swift Hesperange (LUX1) |
| 08.07.21 | | 10 | FC Swift Hesperange | Športni Park (Domžale) |
| 15.07.21 | | 11 | NK Domžale | Stade Josy Barthel |
| Aggregate | Bala Town FC (WAL1) | 02 | Larne FC (NIR1) |
| 08.07.21 |  | 01 | Larne FC | Park Hall Stadium |
| 15.07.21 | | 10 | Bala Town FC | Inver Park |
| Aggregate | Europa FC (GIB1) | 02 | FK Kauno Žalgiris (LTU1) |
| 08.07.21 |  | 00 | FK Kauno Žalgiris | Victoria Stadium (Gibraltar) |
| 15.07.21 | | 20 | Europa FC | Hikvision arena |
| Aggregate | Paide Linnameeskond (EST1) | 14 | Śląsk Wroclaw (POL1) |
| 08.07.21 |  | 12 | Śląsk Wroclaw | Pärnu Rannastaadion |
| 15.07.21 | | 20 | Paide Linnameeskond | Stadion Miejski (Wrocław) |
| Aggregate | Birkirkara FC (MLT1) | 21 | SP La Fiorita (SMR1) |
| 08.07.21 | | 10 | SP La Fiorita | MFA Centenary Stadium (Ta'Qali) |
| 15.07.21 | | 11 | Birkirkara FC | Stadio Olimpico di Serravalle |
| Aggregate | KF Drita (KVX1) | 31 | FK Dečić (MNE1) |
| Aggregate | FK Partizani (ALB1) | 84 | FC Sfîntul Gheorghe (MDA1) |
| 08.07.21 | | 52 | FC Sfîntul Gheorghe | Elbasan Arena |
| 15.07.21 | | 23 | FK Partizani | Complexul Sportiv Raional Orhei |
| Aggregate | FK Velež Mostar (BIH1) | 42 | Coleraine FC (NIR1) |
| 08.07.21 | | 21 | Coleraine FC | Stadion Grbavica |
| 15.07.21 | | 12 | FK Velež Mostar | Mourneview Park |
| Aggregate | FK Sutjeska Nikšić (MNE1) | 21 | FC Gagra (GEO2) |
| 08.07.21 | | 10 | FC Gagra | DG Arena |
| 15.07.21 | | 11 | FK Sutjeska Nikšić | Mikheil Meskhis sakhelobis Stadioni |
| Aggregate | NK Maribor (SVN1) | 20 | FC Urartu (ARM1) |
| 08.07.21 | | 10 | FC Urartu | Stadion Ljudski VRT |
| 15.07.21 | | 01 | NK Maribor | Urartu Stadium |
| Aggregate | SP Tre Penne (SMR1) | 07 | FC Dinamo Batumi (GEO1) |
| 08.07.21 |  | 04 | FC Dinamo Batumi | Stadio Olimpico di Serravalle |
| 15.07.21 | | 30 | SP Tre Penne | Batumi Arena |
| Aggregate | NK Široki Brijeg (BIH1) | 34 | KF Vllaznia Shkodër (ALB1) |
| 08.07.21 |  | 31 | KF Vllaznia Shkodër | Stadion Pecara |
| 15.07.21 | | 30 | NK Široki Brijeg | Stadiumi Loro Boriçi |
| Aggregate | Stjarnan FC (ISL1) | 14 | Bohemians FC (IRL1) |
| 08.07.21 |  | 11 | Bohemians FC | Samsung völlurinn |
| 15.07.21 | | 30 | Stjarnan FC | Aviva Stadium |