Copa Sudamericana
FIFA Region
CONMEBOL
Season
2021
Location
South America
Abbreviation
COPASUD
Summary
The 2021 Copa Sudamericana is South America's second most prestigous club football tournament where top club teams (56 total) from all 10 CONMEBOL F/As (football associations) are represented. It is the equivalent of the UEFA Europa League. The 2021 winner will play in the 2022 Copa Libertadores.
Each F/A is given a minimum of 4 berths, while Argentina and Brazil are each given 6. Stage entry is based on cummulative historical relative performance of each F/A against the other F/As.
Defensa y Justicia (ARG1) won the 2020 Copa Sudamericana.
More Info...
2021 Copa Sudamericana Berths
| F/A | COPALIB Teams | COPASUD Teams |
|---|---|---|
| Argentina | 7 | 6 |
| Boliva | 4 | 4 |
| Brazil | 8 | 6 |
| Chile | 4 | 4 |
| Colombia | 4 | 4 |
| Ecuador | 4 | 4 |
| Paraguay | 4 | 4 |
| Peru | 4 | 4 |
| Uruguay | 4 | 4 |
| Venezuela | 4 | 4 |
Competition Structure
| Stage | # Teams | New Teams Entering This Round | Teams From Previous Round | Format |
|---|---|---|---|---|
| First Round | 32 |
| 16 sets of Home/Away matches, highest aggregate goals advances | |
| Group Stage | 32 | 4 teams eliminated in 2021 Copa Libertadores Third Stage, 1st-6th best 2019-2021 ARG1 Aggregate Table teams not qualified for 2021 Copa Libertadores, 1st-6th best 2020 BRA1 teams not qualified for 2021 Copa Libertadores | 16 winners from First Round | 8 groups of 4 with Home/Away matches against each team in group, top team with most points (win = 3 pts, draw = 1 pt) in each group advance |
| Round of 16 | 16 | eight 3rd place teams from 2021 Copa Libertadores Group Stage | 8 winners from Group Stage | 8 sets of Home/Away matches, highest aggregate goals advances |
| Quarterfinals | 8 | None | 8 winners from Round of 16 | 4 sets of Home/Away matches, highest aggregate goals advances |
| Semifinals | 4 | None | 4 winners from Quarterfinals | 2 sets of Home/Away matches, highest aggregate goals advances |
| Final | 2 | None | 2 winners from Semifinals | Home/Away matches, highest aggregate goals wins |
Final
| Date | Home | Status | Road | Venue | ||||
Sat - 20 Nov 2021
 | 10 | Red Bull Bragantino (BRA1) | Estadio Centenario (Montevideo) |
Semifinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | Red Bull Bragantino (BRA1) | 51 | Club Libertad (PAR1) |
| 22.09.21 |  | 20 | Club Libertad | Estádio Nabi Abi Chedid |
| 29.09.21 | | 13 | Red Bull Bragantino | Estadio Defensores del Chaco (Asunción) |
| Aggregate | CA Peñarol (URU1) | 14 | Atlético Paranaense (BRA1) |
| 23.09.21 |  | 12 | Atlético Paranaense | Estadio Campeón del Siglo |
| 30.09.21 | | 20 | CA Peñarol | Arena da Baixada |
Quarterfinals
| Date | Home | Status | Road | Venue | ||||
| Aggregate | CA Rosario Central (ARG1) | 35 | Red Bull Bragantino (BRA1) |
| 10.08.21 |  | 34 | Red Bull Bragantino | Gigante de Arroyito |
| 17.08.21 | | 10 | CA Rosario Central | Estádio Nabi Abi Chedid |
| Aggregate | Sporting Cristal (PER1) | 14 | CA Peñarol (URU1) |
| 11.08.21 |  | 13 | CA Peñarol | Estadio Nacional de Lima |
| 18.08.21 | | 10 | Sporting Cristal | Estadio Campeón del Siglo |
| Aggregate | LDU Quito (ECU1) | 34 | Atlético Paranaense (BRA1) |
| 12.08.21 |  | 10 | Atlético Paranaense | Estadio Rodrigo Paz Delgado |
| 19.08.21 | | 42 | LDU Quito | Arena da Baixada |
| Aggregate | Santos FC (BRA1) | 22 | Club Libertad (PAR1) |
| 12.08.21 |  | 21 | Club Libertad | Estádio Urbano Caldeira |
| 19.08.21 | | 10 | Santos FC | Estadio Defensores del Chaco (Asunción) |
Round of 16
| Date | Home | Status | Road | Venue | ||||
| Aggregate | LDU Quito (ECU1) | 22 | Grêmio (BRA1) |
| Aggregate | América de Cali (COL1) | 15 | Atlético Paranaense (BRA1) |
| 13.07.21 |  | 01 | Atlético Paranaense | Estadio Hernán Ramírez Villegas |
| 20.07.21 | | 41 | América de Cali | Arena da Baixada |
| Aggregate | Sporting Cristal (PER1) | 32 | Arsenal de Sarandí (ARG1) |
| 14.07.21 | | 21 | Arsenal de Sarandí | Estadio Nacional de Lima |
| 21.07.21 | | 11 | Sporting Cristal | Estadio Julio Humberto Grondona |
| Aggregate | CSD Independiente (ECU1) | 13 | Red Bull Bragantino (BRA1) |
| 14.07.21 |  | 02 | Red Bull Bragantino | Estadio Banco Guayaquil |
| 21.07.21 | | 11 | CSD Independiente | Estádio Nabi Abi Chedid |
| Aggregate | Junior de Barranquilla (COL1) | 44 | Club Libertad (PAR1) |
| 14.07.21 |  | 34 | Club Libertad | Estadio Metropolitano Roberto Meléndez |
| 21.07.21 | | 01 | Junior de Barranquilla | Estadio Defensores del Chaco (Asunción) |
| Aggregate | Santos FC (BRA1) | 21 | Independiente (ARG1) |
| 15.07.21 | | 10 | Independiente | Estádio Urbano Caldeira |
| 22.07.21 | | 11 | Santos FC | Estadio Libertadores de América |
| Aggregate | Nacional (URU1) | 22 | CA Peñarol (URU1) |
| 15.07.21 |  | 12 | CA Peñarol | Estadio Gran Parque Central |
| 22.07.21 | | 01 | Nacional | Estadio Campeón del Siglo |
| Aggregate | Deportivo Táchira FC (VEN1) | 23 | CA Rosario Central (ARG1) |
| 15.07.21 |  | 22 | CA Rosario Central | Estadio Polideportivo de Pueblo Nuevo |
| 22.07.21 | | 10 | Deportivo Táchira FC | Gigante de Arroyito |
Group Stage
| Group A | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | CA Rosario Central (ARG1) | 6 | 3 -2-1 | 11 | - | 10 | 3 | 7 | 3 | 2 -1-0 | 7 | 7 | 0 | 7 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 |
| 2 | CD Huachipato (CHI1) | 6 | 2 -2-2 | 8 | - | 4 | 10 | -6 | 3 | 0 -2-1 | 2 | 1 | 4 | -3 | 3 | 2 -0-1 | 6 | 3 | 6 | -3 |
| 3 | San Lorenzo (ARG1) | 6 | 2 -1-3 | 7 | - | 7 | 6 | 1 | 3 | 0 -1-2 | 1 | 2 | 4 | -2 | 3 | 2 -0-1 | 6 | 5 | 2 | 3 |
| 4 | 12 de Octubre (PAR2) | 6 | 1 -3-2 | 6 | - | 3 | 5 | -2 | 3 | 1 -0-2 | 3 | 2 | 4 | -2 | 3 | 0 -3-0 | 3 | 1 | 1 | 0 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 10 | CA Rosario Central | Estadio Luis Alberto Salinas Tanasio |
| 21.04.21 |  | 01 | CD Huachipato | Estadio Pedro Bidegain |
| 27.04.21 | | 00 | 12 de Octubre | Estadio CAP |
| 28.04.21 | | 20 | San Lorenzo | Gigante de Arroyito |
| 05.05.21 | | 11 | Rosario Central | Estadio Sausalito |
| 06.05.21 | | 11 | 12 de Octubre | Estadio Pedro Bidegain |
| 12.05.21 | | 12 | CD Huachipato | Estadio Luís Alfonso Giagni |
| 12 | CA Rosario Central | Estadio Pedro Bidegain |
| 19.05.21 | | 50 | CD Huachipato | Estadio Florencio Sola |
| 20.05.21 | | 02 | San Lorenzo | Estadio Luís Alfonso Giagni |
| 26.05.21 | | 00 | 12 de Octubre | Estadio Florencio Sola |
| 03 | San Lorenzo | Estadio Sausalito |
| Group B | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Independiente (ARG1) | 6 | 4 -2-0 | 14 | - | 11 | 5 | 6 | 3 | 3 -0-0 | 9 | 5 | 1 | 4 | 3 | 1 -2-0 | 5 | 6 | 4 | 2 |
| 2 | Montevideo City Torque (URU2) | 6 | 3 -2-1 | 11 | - | 15 | 7 | 8 | 3 | 1 -2-0 | 5 | 6 | 2 | 4 | 3 | 2 -0-1 | 6 | 9 | 5 | 4 |
| 3 | EC Bahia (BRA1) | 6 | 2 -2-2 | 8 | - | 11 | 8 | 3 | 3 | 1 -1-1 | 4 | 9 | 6 | 3 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 |
| 4 | CD Guabirá (BOL1) | 6 | 0 -0-6 | 0 | - | 1 | 18 | -17 | 3 | 0 -0-3 | 0 | 1 | 8 | -7 | 3 | 0 -0-3 | 0 | 0 | 10 | -10 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 21.04.21 |  | 13 | Independiente | Estadio Gilberto Parada |
 | 11 | EC Bahia | Estadio Centenario (Montevideo) |
| 27.04.21 | | 50 | CD Guabirá | Arena Fonte Nova |
| 28.04.21 | | 31 | Montevideo City Torque | Estadio Libertadores de América |
| 04.05.21 | | 22 | Independiente | Arena Fonte Nova |
| 05.05.21 | | 40 | CD Guabirá | Estadio Parque Alfredo Victor Viera |
| 11.05.21 | | 11 | Independiente | Estadio Parque Alfredo Victor Viera |
| 13.05.21 | | 01 | EC Bahia | Estadio Gilberto Parada |
| 18.05.21 | | 10 | EC Bahia | Estadio Libertadores de América |
| 20.05.21 | | 04 | Montevideo City Torque | Estadio Gilberto Parada |
| 26.05.21 | | 10 | CD Guabirá | Estadio Libertadores de América |
| 24 | Montevideo City Torque | Estádio de Pitaçu |
| Group C | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Arsenal de Sarandí (ARG2) | 6 | 3 -2-1 | 11 | - | 9 | 4 | 5 | 3 | 2 -1-0 | 7 | 6 | 1 | 5 | 3 | 1 -1-1 | 4 | 3 | 3 | 0 |
| 2 | Ceará (BRA2) | 6 | 2 -3-1 | 9 | - | 5 | 2 | 3 | 3 | 2 -1-0 | 7 | 5 | 1 | 4 | 3 | 0 -2-1 | 2 | 0 | 1 | -1 |
| 3 | FC Bolívar (BOL1) | 6 | 1 -3-2 | 6 | - | 5 | 8 | -3 | 3 | 1 -2-0 | 5 | 4 | 3 | 1 | 3 | 0 -1-2 | 1 | 1 | 5 | -4 |
| 4 | Club Jorge Wilstermann (BOL1) | 6 | 1 -2-3 | 5 | - | 5 | 10 | -5 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 | 3 | 0 -1-2 | 1 | 3 | 8 | -5 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 21.04.21 |  | 31 | Club Jorge Wilstermann | Castelão (Ceará) |
| 22.04.21 |  | 21 | Arsenal de Sarandí | Estadio Hernando Siles |
| 27.04.21 | | 00 | Ceará | Estadio Julio Humberto Grondona |
| 29.04.21 | | 00 | FC Bolívar | Estadio Félix Capriles |
| 05.05.21 | | 00 | Ceara | Estadio Hernando Siles |
| 06.05.21 | | 30 | Wilstermann | Estadio Julio Humberto Grondona |
| 12.05.21 | | 00 | Arsenal de Sarandí | Castelão (Ceará) |
| 22 | Club Jorge Wilstermann | Estadio Hernando Siles |
| 19.05.21 | | 12 | Arsenal de Sarandí | Estadio Félix Capriles |
| 20.05.21 | | 20 | FC Bolívar | Castelão (Ceará) |
| 27.05.21 | | 10 | Ceará | Estadio Félix Capriles |
| 31 | FC Bolívar | Estadio Julio Humberto Grondona |
| Group D | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Atlético Paranaense (BRA1) | 6 | 5 -0-1 | 15 | - | 8 | 1 | 7 | 3 | 3 -0-0 | 9 | 6 | 0 | 6 | 3 | 2 -0-1 | 6 | 2 | 1 | 1 |
| 2 | FBC Melgar (PER1) | 6 | 3 -1-2 | 10 | - | 7 | 5 | 2 | 3 | 2 -1-0 | 7 | 3 | 0 | 3 | 3 | 1 -0-2 | 3 | 4 | 5 | -1 |
| 3 | SD Aucas (ECU1) | 6 | 2 -0-4 | 6 | - | 7 | 11 | -4 | 3 | 2 -0-1 | 6 | 5 | 2 | 3 | 3 | 0 -0-3 | 0 | 2 | 9 | -7 |
| 4 | Metropolitanos FC (VEN1) | 6 | 1 -1-4 | 4 | - | 5 | 10 | -5 | 3 | 1 -0-2 | 3 | 5 | 6 | -1 | 3 | 0 -1-2 | 1 | 0 | 4 | -4 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 23 | FBC Melgar | Estadio Olímpico de la UCV |
 | 01 | Atlético Paranaense | Estadio Gonzalo Pozo Ripalda |
| 28.04.21 | | 10 | Metropolitanos FC | Arena da Baixada |
| 20 | SD Aucas | Estadio Nacional de Lima |
| 04.05.21 | | 32 | SD Aucas | Estadio Olímpico de la UCV |
| 10 | Atlético Paranaense | Estadio Nacional de Lima |
| 11.05.21 | | 01 | Atlético Paranaense | Estadio Olímpico de la UCV |
| 13.05.21 | | 21 | FBC Melgar | Estadio Gonzalo Pozo Ripalda |
| 19.05.21 | | 30 | Metropolitanos FC | Estadio Gonzalo Pozo Ripalda |
| 10 | FBC Melgar | Arena da Baixada |
| 27.05.21 | | 00 | Metropolitanos FC | Estadio Monumental (Lima) |
| 40 | SD Aucas | Arena da Baixada |
| Group E | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | CA Peñarol (URU1) | 6 | 4 -1-1 | 13 | - | 15 | 3 | 12 | 3 | 3 -0-0 | 9 | 12 | 1 | 11 | 3 | 1 -1-1 | 4 | 3 | 2 | 1 |
| 2 | Corinthians (BRA1) | 6 | 3 -1-2 | 10 | - | 12 | 6 | 6 | 3 | 2 -0-1 | 6 | 9 | 2 | 7 | 3 | 1 -1-1 | 4 | 3 | 4 | -1 |
| 3 | Club River Plate (PAR2) | 6 | 3 -1-2 | 10 | - | 6 | 10 | -4 | 3 | 2 -1-0 | 7 | 4 | 2 | 2 | 3 | 1 -0-2 | 3 | 2 | 8 | -6 |
| 4 | Sport Huancayo (PER1) | 6 | 0 -1-5 | 1 | - | 3 | 17 | -14 | 3 | 0 -1-2 | 1 | 1 | 5 | -4 | 3 | 0 -0-3 | 0 | 2 | 12 | -10 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 22.04.21 |  | 00 | Corinthians | Estadio River Plate |
| 51 | Sport Huancayo | Estadio Campeón del Siglo |
| 29.04.21 | | 12 | Club River Plate | Estadio Nacional de Lima |
| 02 | CA Peñarol | Neo Química Arena |
| 06.05.21 | | 03 | Corinthians | Estadio Nacional de Lima |
| 30 | Club River Plate | Estadio Campeón del Siglo |
| 13.05.21 | | 21 | Sport Huancayo | Estadio Defensores del Chaco (Asunción) |
| 40 | Corinthians | Estadio Campeón del Siglo |
| 18.05.21 | | 21 | CA Peñarol | Estadio Defensores del Chaco (Asunción) |
| 20.05.21 | | 50 | Sport Huancayo | Neo Química Arena |
| 26.05.21 | | 40 | Club River Plate | Neo Química Arena |
| 00 | CA Peñarol | Estadio Monumental (Lima) |
| Group F | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Club Libertad (PAR1) | 6 | 4 -1-1 | 13 | - | 9 | 4 | 5 | 3 | 2 -0-1 | 6 | 4 | 2 | 2 | 3 | 2 -1-0 | 7 | 5 | 2 | 3 |
| 2 | Goianiense (BRA1) | 6 | 2 -4-0 | 10 | - | 4 | 2 | 2 | 3 | 0 -3-0 | 3 | 0 | 0 | 0 | 3 | 2 -1-0 | 7 | 4 | 2 | 2 |
| 3 | Newell's Old Boys (ARG1) | 6 | 2 -2-2 | 8 | - | 6 | 6 | 0 | 3 | 1 -1-1 | 4 | 5 | 5 | 0 | 3 | 1 -1-1 | 4 | 1 | 1 | 0 |
| 4 | CD Palestino (CHI1) | 6 | 0 -1-5 | 1 | - | 2 | 9 | -7 | 3 | 0 -0-3 | 0 | 1 | 4 | -3 | 3 | 0 -1-2 | 1 | 1 | 5 | -4 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 20.04.21 |  | 00 | Newell's Old Boys | Estádio Serra Dourada |
| 22.04.21 | | 20 | CD Palestino | Estadio Dr Nicolás Léoz |
| 29.04.21 | | 01 | Goianiense | Estadio Parque El Teniente |
| 13 | Club Libertad | Estadio Marcelo Bielsa |
| 04.05.21 | | 01 | Newell's Old Boys | Estadio Parque El Teniente |
| 06.05.21 | | 12 | Atletico GO | Estadio Defensores del Chaco (Asunción) |
| 12.05.21 | | 00 | CD Palestino | Estádio Antônio Accioly |
| 13.05.21 | | 10 | Newell's Old Boys | Estadio Dr Nicolás Léoz |
| 19.05.21 | | 00 | Club Libertad | Estádio Antônio Accioly |
| 20.05.21 | | 31 | CD Palestino | Estadio Marcelo Bielsa |
| 25.05.21 | | 11 | Goianiense | Estadio Marcelo Bielsa |
| 12 | Club Libertad | Estadio Parque El Teniente |
| Group G | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Red Bull Bragantino (BRA1) | 6 | 4 -0-2 | 12 | - | 7 | 6 | 1 | 3 | 2 -0-1 | 6 | 4 | 2 | 2 | 3 | 2 -0-1 | 6 | 3 | 4 | -1 |
| 2 | ES Emelec (ECU1) | 6 | 3 -1-2 | 10 | - | 9 | 8 | 1 | 3 | 2 -0-1 | 6 | 6 | 4 | 2 | 3 | 1 -1-1 | 4 | 3 | 4 | -1 |
| 3 | CA Talleres (ARG1) | 6 | 2 -2-2 | 8 | - | 7 | 5 | 2 | 3 | 0 -1-2 | 1 | 1 | 3 | -2 | 3 | 2 -1-0 | 7 | 6 | 2 | 4 |
| 4 | Deportes Tolima (COL1) | 6 | 0 -3-3 | 3 | - | 4 | 8 | -4 | 3 | 0 -2-1 | 2 | 3 | 4 | -1 | 3 | 0 -1-2 | 1 | 1 | 4 | -3 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
| 22.04.21 |  | 12 | ES Emelec | Estadio Mario Alberto Kempes |
| 21 | Deportes Tolima | Estádio Nabi Abi Chedid |
| 28.04.21 | | 30 | Red Bull Bragantino | Estadio Banco del Pacífico |
| 11 | CA Talleres | Estadio Manuel Murillo Toro |
| 05.05.21 | | 01 | Talleres | Estádio Nabi Abi Chedid |
| 07.05.21 | | 11 | ES Emelec | Estadio Monumental (Lima) |
| 11.05.21 | | 20 | ES Emelec | Estádio Nabi Abi Chedid |
| 00 | Deportes Tolima | Estadio Mario Alberto Kempes |
| 18.05.21 | | 01 | Red Bull Bragantino | Estadio Mario Alberto Kempes |
| 19.05.21 | | 20 | Deportes Tolima | Estadio Banco del Pacífico |
| 25.05.21 | | 14 | CA Talleres | Estadio Banco del Pacífico |
| 12 | Red Bull Bragantino | Estadio Polideportivo de Pueblo Nuevo |
| Group H | League | Home | Road | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| POS | MP | W - D - L | PTS | CPTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | MP | W - D - L | PTS | GF | GA | GD | |
| 1 | Grêmio (BRA1) | 6 | 5 -1-0 | 16 | - | 21 | 5 | 16 | 3 | 3 -0-0 | 9 | 13 | 2 | 11 | 3 | 2 -1-0 | 7 | 8 | 3 | 5 |
| 2 | Lanús (ARG1) | 6 | 3 -1-2 | 10 | - | 8 | 6 | 2 | 3 | 1 -1-1 | 4 | 5 | 3 | 2 | 3 | 2 -0-1 | 6 | 3 | 3 | 0 |
| 3 | CD La Equidad (COL1) | 6 | 2 -1-3 | 7 | - | 6 | 9 | -3 | 3 | 1 -1-1 | 4 | 2 | 2 | 0 | 3 | 1 -0-2 | 3 | 4 | 7 | -3 |
| 4 | Aragua FC (VEN2) | 6 | 0 -1-5 | 1 | - | 4 | 19 | -15 | 3 | 0 -0-3 | 0 | 3 | 9 | -6 | 3 | 0 -1-2 | 1 | 1 | 10 | -9 |
Round of 16 | ||||||||||||||||||||
| Date | Home | Status | Road | Venue | ||||
 | 21 | CD La Equidad | Arena do Grêmio |
| 29.04.21 | | 21 | Aragua FC | Estadio Hernán Ramírez Villegas |
| 01 | Lanús | Estadio Defensores del Chaco (Asunción) |
| 13.05.21 | | 12 | CD La Equidad | Estadio Olímpico de la UCV |
| 20.05.21 | | 41 | CD La Equidad | Estadio Ciudad de Lanús |
| 00 | Grêmio | Estadio Bellavista |
First Round
| Date | Home | Status | Road | Venue | ||||
| Aggregate | 12 de Octubre (PAR1) | 00 | Club Nacional (PAR1) |
| 16.03.21 | | 00 | Club Nacional | Estadio Luís Alfonso Giagni |
| 06.04.21 | | 00 | 12 de Octubre | Estadio Defensores del Chaco (Asunción) | ||
| 12 de Octubre advances on PKs (5-4) | ||||||
| Aggregate | CSD Macará (ECU1) | 24 | ES Emelec (ECU1) |
| 16.03.21 |  | 22 | ES Emelec | Estadio Bellavista |
| 06.04.21 | | 20 | CSD Macará | Estadio Banco del Pacífico |
| Aggregate | Deportes Tolima (COL1) | 30 | AC Deportivo Cali (COL1) |
| 16.03.21 | | 30 | AC Deportivo Cali | Estadio Manuel Murillo Toro |
| 06.04.21 | | 00 | Deportes Tolima | Estadio Deportivo Cali |
| Aggregate | Deportes Antofagasta (CHI1) | 04 | CD Huachipato (CHI1) |
| 16.03.21 |  | 01 | CD Huachipato | Estadio Regional de Antofagasta |
| 06.04.21 | | 30 | Deportes Antofagasta | Estadio CAP |
| Aggregate | CD Guabirá (BOL1) | 62 | CA Nacional Potosí (BOL1) |
| 17.03.21 | | 41 | CA Nacional Potosí | Estadio Gilberto Parada |
| 07.04.21 | | 12 | CD Guabirá | Estadio Víctor Agustín Ugarte |
| Aggregate | Aragua FC (VEN1) | 22 | Mineros de Guayana (VEN1) |
| 17.03.21 | | 01 | Mineros de Guayana | Estadio Olímpico Hermanos Ghersi Páez |
| 07.04.21 | | 12 | Aragua FC | Estadio CTE Cachamay | ||
| Aragua FC advances w/more away goals (2-1) | ||||||
| Aggregate | Club Jorge Wilstermann (BOL1) | 42 | Atlético Palmaflor (BOL1) |
| 17.03.21 | | 21 | Atlético Palmaflor | Estadio Félix Capriles |
| 07.04.21 | | 12 | Club Jorge Wilstermann | Estadio Félix Capriles |
| Aggregate | UTC (PER1) | 05 | Sport Huancayo (PER1) |
| 17.03.21 |  | 01 | Sport Huancayo | Estadio Garcilaso |
| 07.04.21 | | 40 | UTC | Estadio Monumental (Lima) |
| Aggregate | Metropolitanos FC (VEN1) | 30 | Academia Puerto Cabello (VEN1) |
| 18.03.21 | | 20 | Academia Puerto Cabello | Estadio Olímpico de la UCV |
| 08.04.21 | | 01 | Metropolitanos FC | Estadio Polideportivo Misael Delgado |
| Aggregate | SD Aucas (ECU1) | 51 | Guayaquil City FC (ECU1) |
| 18.03.21 | | 21 | Guayaquil City FC | Estadio Gonzalo Pozo Ripalda |
| 08.04.21 | | 03 | SD Aucas | Estadio Christian Benítez Betancourt |
| Aggregate | Guaireña FC (PAR1) | 36 | Club River Plate (PAR1) |
| 18.03.21 |  | 12 | Club River Plate | Estadio Defensores del Chaco (Asunción) |
| 08.04.21 | | 42 | Guaireña FC | Estadio Defensores del Chaco (Asunción) |
| Aggregate | CD La Equidad (COL1) | 32 | Deportivo Pasto (COL1) |
| 18.03.21 | | 12 | Deportivo Pasto | Estadio Metropolitano de Techo |
| 08.04.21 | | 02 | CD La Equidad | Estadio Departamental Libertad |
| Aggregate | CD Carlos A Mannucci (PER1) | 35 | FBC Melgar (PER1) |
| 18.03.21 |  | 12 | FBC Melgar | Estadio Monumental (Lima) |
| 08.04.21 | | 32 | CD Carlos A Mannucci | Estadio Nacional de Lima |
| Aggregate | CD Cobresal (CHI1) | 12 | CD Palestino (CHI1) |
| 18.03.21 |  | 00 | CD Palestino | Estadio El Cobre |
| 08.04.21 | | 21 | CD Cobresal | Estadio San Carlos de Apoquindo |
| Aggregate | Cerro Largo FC (URU1) | 36 | CA Peñarol (URU1) |
| 06.04.21 |  | 22 | CA Peñarol | Estadio Parque Alfredo Victor Viera |
| 13.04.21 | | 41 | Cerro Largo FC | Estadio Campeón del Siglo |
| Aggregate | Montevideo City Torque (URU1) | 20 | CA Fénix (URU1) |
| 07.04.21 | | 00 | CA Fénix | Estadio Centenario (Montevideo) |
| 14.04.21 | | 02 | Montevideo City Torque | Estadio Parque Alfredo Victor Viera |